瑞马唑仑与丙泊酚在无痛胃肠镜患者中的麻醉比较  

Anesthesia Comparison between Remimazolam and Propofol in Painless Gastroenteroscopy Patients

作　　者：王梅[1] 陈鑫[1] 顾政 WANG Mei;CHEN Xin;GU Zheng(The Affiliated Taizhou People's Hospital of Nanjing Medical University,Taizhou Jiangsu 225300,China)

机构地区：[1]南京医科大学附属泰州人民医院麻醉科,江苏泰州225300

出　　处：《泰州职业技术学院学报》2024年第1期68-71,96,共5页Journal of Taizhou Polytechnic College

摘　　要：目的探讨瑞马唑仑与丙泊酚用于无痛胃肠镜患者中的麻醉优势比较。方法选取2021年10月至12月接受无痛胃肠镜检查的64例患者作为研究对象,随机分为对照组(P组)和实验组(R组),两组均给予瑞芬太尼0.5ug/kg静脉注射后以0.05ug/kg/min持续静脉泵注,P组静脉注射丙泊酚1.5mg/kg,每5min追加0.3mg/kg,R组静脉注射瑞马唑仑0.2mg/kg,每5min追加0.05mg/kg。Ramsay镇静评分6分时开始进镜检查,若评分不足6分,间隔1min追加1次,直至评分达6分后开始内镜检查。记录给药前、给药后1min、2min、3min、5min及离室时收缩压、心率、呼吸频率、血氧饱和度;记录麻醉诱导起效时间、苏醒时间、离室时间;记录追加给药次数、补救给药次数、体动次数;记录注射痛、低氧血症、呼吸抑制、低血压、心动过缓、恶心、呕吐、眩晕发生情况。结果R组诱导时间低于P组,离室时间高于P组,差异有统计学意义(P<0.05);R组注射痛、低血压、呼吸抑制、心率减慢发生率均低于P组,差异有统计学意义(P<0.05)。R组T3、T5收缩压高于P组,差异有统计学意义(P<0.05)。与T0及R组比较,P组T1、T3、T4心率均较低,P组T2呼吸频率较低,差异有统计学意义(P<0.05)。结论在无痛胃肠镜检查镇静中,当瑞马唑仑与丙泊酚达到相同的镇静效果时,瑞马唑仑更加优于丙泊酚。Objective To investigate the anesthesia comparison between Remimazolam and propofol in patients with painless gastroenteroscopy.Method We selected 64 patients in our study,which were randomly divided into two groups:control group(group P)and experimental group(group R),who received painless gastroenteroscopy from October to December 2021.Both groups were given intravenous injection(iv)of remifentanil 0.5ug/kg followed by continuous intravenous pump injection of 0.05ug/kg/min.Then group P was given intravenous injection of propofol 1.5mg/kg,followed by 0.3mg/kg propofol iv every 5min,while group R was given Remimazolam 0.2mg/kg,followed by 0.05mg/kg Remimazolam iv every 5min.The endoscopy was performed while Ramsay's score was 6,If not,add propofol or Remimazolam every 1min.The data were recorded before administration,1min,2min,3min,5min after administration and when leaving recovery room,which included Systolic blood pressure(SBP),heart rate(HR),respiratory rate(RR)and oxygen saturation.The data we recorded included the duration of anesthesia induction,recovery time and exit time,the times of additional administration,remedial administration and body movement,and also included injection pain,hypoxemia,respiratory depression,hypotension,bradycardia,nausea,vomiting and vertigo.Results The induction time of R group was shorter than that of P group,but the exit time was longer;the incidence of injection pain,hypotension,respiratory depression and slow HR in group R was less;the differences were statistically significant(P<0.05).SBP of T3 and T5 in group R were higher,the difference was statistically significant(P<0.05).Compared with TO and R groups,the HR of T1,T3 and T4 in group P was lower,the RR of T2 in group P was lower,the differences were statistically significant(P<0.05).Conclusion Remimazolam was superior to propofol when it achieves the same sedative effect as propofol in painless gastroenteroscopy.

关 键 词：瑞马唑仑 丙泊酚 无痛胃肠镜 麻醉比较 

分 类 号：R614[医药卫生—麻醉学]