母亲孕期风险暴露对儿童焦虑症及其亚型脑结构和功能影响的关联分析  

Correlation Analysis of the Maternal Risk Exposure During Pregnancy Impacts on the Brain Structure and Function of Children with Anxiety Disorders

作　　者：赵飘飘 顾薪睿 刘宇 於葛畅[4] 范华鑫 廉正旭 胡叶辰 杨森友 吴欣然 张捷 ZHAO Piao-piao;GU Xin-rui;LIU Yu;YU Ge-chang;FAN Hua-xin;LIAN Zheng-xu;HU Ye-chen;YANG Sen-you;WU Xin-ran;ZHANG Jie(Institute of Science and Technology for Brain-Inspired Intelligence,Fudan University,Shanghai 200433,China;Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University),Ministry of Education,Shanghai 200433,China;Sino-European School of Technology of Shanghai University,Shanghai 200072,China;Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong 999077,China)

机构地区：[1]复旦大学类脑智能科学与技术研究院,上海200433 [2]复旦大学计算神经科学与类脑智能教育部重点实验室,上海200433 [3]上海大学中欧工程技术学院,上海200072 [4]香港中文大学医学院,中国香港999077

出　　处：《中国临床心理学杂志》2024年第1期57-64,共8页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金(项目批准号:61973086)。

摘　　要：目的:探究母亲孕期风险暴露对儿童焦虑症及其亚型脑结构和功能的影响。方法:基于ABCD(Adolescent Brain Cognitive Development)数据库5686名儿童(平均年龄9.95岁,其中焦虑症儿童2743名)数据,采用线性混合效应模型,比较焦虑组和焦虑症亚型组与健康组儿童孕期风险暴露、大脑结构以及静息态功能连接的差异,并且探究母亲孕期风险因素与儿童脑结构以及静息态功能连接的关联。结果:(1)与健康组对比,焦虑组儿童表现出母亲孕期风险暴露(如接受医疗护理次数)增加和颞上回等皮层厚度增加、脑岛等表面积降低以及扣带顶叶网络-尾状核等的功能连接增强。(2)母亲孕期医疗护理与焦虑组儿童左侧颞上回厚度增加有关。(3)母亲孕期风险暴露(如严重贫血、孕期医疗护理次数)是儿童焦虑症及其亚型的共同风险,同时焦虑症亚型儿童大脑结构和功能连接也表现出异常。结论:母亲孕期风险暴露是儿童焦虑症的重要风险因素,其长期影响可能与脑结构和功能的异常有关。Objective:This study aims to investigate the impact of maternal risk exposure during pregnancy on the brain structure and function of children with anxiety disorders and its subtypes.Methods:In this cross-sectional analysis,the data included 5686 children(average age:9.95 years old,2743 children with anxiety disorders)obtained from ABCD(Adolescent Brain Cognitive Development)database.Linear mixed-effects model was employed to compare the differences in pregnant risk factors,brain structure,and resting-state functional connectivity among the anxiety group,anxiety subtype group,and the healthy control group.We also examined the relationship between maternal prenatal risk factors and children's brain structure along with resting-state functional connectivity.Results:(1)Compared to the healthy group,children in the anxiety group exhibited more maternal risk exposure during pregnancy(e.g.,the experience of medical care),thicker cortical thickness in the superior temporal gyrus,smaller surface area in the insula,and enhanced functional connectivity between the cingulate-parietal network and the caudate nucleus.(2)Mothers'peripartum medical care was associated with children's increased thickness of the left superior temporal gyrus.(3)Prenatal risk exposures(e.g.,severe anemia,medical care)were identified as common risk factors for children's anxiety disorder and its subtypes,and abnormalities also observed in brain structure and connectivity in children.Conclusion:Maternal risk exposure during pregnancy is a critical risk factor for childhood anxiety disorders,and its long-term effects may be attributed to abnormalities in brain structure and function.

关 键 词：儿童焦虑症 脑结构 静息态功能连接 母亲孕期风险暴露 

分 类 号：R395.2[哲学宗教—心理学]