梅毒螺旋体与母胎界面细胞相互作用影响妊娠结局的机制研究进展  

Progress in impact of interaction between Treponema pallidum and maternal-fetal interface cells on pregnancy outcomes

作　　者：黄少彬 熊顺 刘兆平 张晓红 赵飞骏 HUANG Shaobin;XIONG Shun;LIU Zhaoping;ZHANG Xiaohong;ZHAO Feijun(Institute of Pathogenic Biology,Hengyang Medical College and Key Laboratory of Special Pathogen Prevention and Con-trol of Hunan Province,University of South China,Hengyang 421001,China;Department of Clinical Laboratory and In-stitute of Infectious Diseases,The First Affiliated Hospital of University of South China,Hengyang 421001,China)

机构地区：[1]南华大学衡阳医学院病原生物学研究所/特殊病原体防控湖南省重点实验室,湖南衡阳421001 [2]南华大学附属第一医院检验医学中心/感染性疾病研究所,湖南衡阳421001

出　　处：《中国病理生理杂志》2024年第2期351-357,共7页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81971980);湖南省出生缺陷协同防治重大专项(No.2019SK1010);湖南省自然科学基金资助项目(No.2021JJ30604);湖南省卫健委重点课题(No.20221064723)。

摘　　要：梅毒是由梅毒螺旋体(Treponema pallidum,Tp)感染引起的一种慢性、性传播疾病[1]。近十年来,梅毒在世界范围内流行,特别是在非洲、东南亚、西欧、俄罗斯和中国,并在这些地区造成了严重的公共卫生问题[2-3]。梅毒发病率逐年上升,先天性梅毒(con-genital syphilis,CS)发生率也一直处于较高水平[4-5]。CS是由Tp经胎盘垂直传播感染胎儿的一种先天感染性疾病,可发生于妊娠任何阶段.Treponema pallidum(Tp),a common sexually transmitted pathogen,can infect the fetus via placental vertical transmission,leading to congenital syphilis(CS).This infection results in adverse pregnancy outcomes,such as stillbirth,miscarriage,preterm birth,and fetal growth restriction.However,the exact pathogenesis remains unclear.Studies indicate that patients with early syphilis primarily exhibit pro-inflammatory immune responses.The Tp has been proven to induce dysfunction in various immune cells and abnormal expression of cytokines,potentially disrupting immune tolerance homeostasis and leading to adverse pregnancy outcomes.Grounded in the current understanding of CS and maternal-fetal immunology by scholars both domestically and internationally,this paper provides a comprehensive review of the potential mechanisms of Tp interacting with the cells of the maternal-fetal interface,ultimately leading to adverse pregnancy outcomes.It summarizes the pathogenesis characteristics,clinical manifestations,and maternal-fetal immune responses of CS.

关 键 词：梅毒螺旋体 先天性梅毒 母胎免疫 不良妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学] R759.1[医药卫生—临床医学] R363.2