基于数据挖掘探析国家专利中药复方治疗PACG的用药规律  

Analysis of Medication Patterns for Treating PACG in Traditional Chinese Medicine Formulations Based on Data Mining of National Patents

作　　者：周日龙 罗紫玉 陈志松 夏燕婷[2] 吴琼 廖良[2] ZHOU Rilong;LUO Ziyu;CHEN Zhisong;XIA Yanting;WU Qiong;LIAO Liang(Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院,北京100078 [3]首都医科大学附属北京同仁医院,北京100730

出　　处：《中国中医眼科杂志》2024年第2期110-117,共8页China Journal of Chinese Ophthalmology

基　　金：国家自然科学基金项目(81973909)。

摘　　要：目的基于数据挖掘探析国家专利中药复方治疗原发性闭角型青光眼(PACG)的用药规律。方法纳入建库至2022年12月31日中国专利公布公告网站中治疗PACG的中药复方专利。采用Excel软件对中药复方建立数据库并进行数据处理,运用R语言进行频数统计、功效归类、性味归经、关联规则及聚类分析。结果(1)一般情况:共纳入专利160项,共涉及药物510味,药物累计频次2,055次。(2)性味归经:四气为寒性药最多,共27味(49.09%);五味以甘味药最多,共71味(47.97%);归经以肝经最多,共38味(25.00%)。(3)高频中药使用频次:使用频次>10次的中药(高频中药)有55味,使用频次最高为枸杞子(46次,28.75%),其次为熟地黄(42次,26.25%)、菊花(41次,25.63%)、甘草(39次,24.38%)、决明子(38次,23.75%)。(4)高频中药功效归类分析:排名前5位为清热药(14味,25.45%)、补虚药(12味,21.82%)、解表药(8味,14.55%)、平肝息风药(5味,9.09%)、利水渗湿药(4味,7.27%)。(5)关联规则分析:高频药对排名前5位分别为:菊花-枸杞子(21次,9.21%)、茯苓-枸杞子(20次,8.77%)、决明子-菊花(20次,8.77%)、泽泻-菊花(18次,7.89%)、熟地黄-菊花(18次,7.89%)。(6)聚类分析:共得到6类有效组合。第Ⅰ类功效为清热泻火,疏肝解郁;第Ⅱ类功效为祛风解表,凉血解毒;第Ⅲ类功效为活血祛瘀,通经止痛;第Ⅳ类功效为滋肾养阴,平肝潜阳;第Ⅴ类功效为滋补肝肾,化痰泻火;第Ⅵ类功效为滋补肝肾,祛风化火。结论国家专利中药复方治疗PACG有规律可循,多从肝、肾、脾入手,组方寒温并用,虚实兼顾,标本兼治,主要针对风、火、痰、虚、郁、瘀六类致病因素。OBJECTIVE This study explores the medication patterns of Traditional Chinese Medicine(TCM)formulations for treating primary angle-closure glaucoma(PACG)based on data mining of national patents.METHODS Patents for Chinese medicine formulations treating PACG were included from the Chinese Patent Public Announcement website established until December 31,2022.Excel software was used to establish a database for Chinese medicine formulations,and R language was employed for frequency statistics,classification of properties and flavors,association rules,and clustering analysis.RESULTS(1)General information:A total of 160 patents were included,involving 510 medicinal ingredients with a cumulative frequency of 2,055 occurrences.(2)Classification of properties and flavors:Cold-natured medicines were the most common,with 27 flavors(49.09%).Sweet-flavored medicines were the most common among the five tastes,with 71 flavors(47.97%).The liver meridian had the highest number of medicinal ingredients(38 flavors,25.00%).(3)High-frequency use of Chinese medicines:55 high-frequency Chinese medicines(used more than 10 times)were identified,with Lycium barbarum(46 times,28.75%)being the most frequently used,followed by Rehmannia glutinosa(42 times,26.25%),Chrysanthemum morifolium(41 times,25.63%),Glycyrrhiza uralensis(39 times,24.38%),and Cassia seed(38 times,23.75%).(4)Analysis of high-frequency Chinese medicine efficacy classification:The top five efficacy classifications for high-frequency Chinese medicines were heat-clearing medicines(14 flavors,25.45%),tonifying deficiency medicines(12 flavors,21.82%),exterior-releasing medicines(eight flavors,14.55%),liver-calming and wind-extinguishing medicines(five flavors,9.09%),and diuretic and dampness-dispelling medicines(four flavors,7.27%).(5)Association rules analysis:The top five combinations were Chrysanthemum morifolium-Lycium barbarum(21 times,9.21%),Poria cocos-Lycium barbarum(20 times,8.77%),Cassia seed-Chrysanthemum morifolium(20 times,8.77%),Alisma orientale-Chrysanthemum morif

关 键 词：原发性闭角型青光眼 国家专利 中药复方 数据挖掘 

分 类 号：R276.7[医药卫生—中医五官科学]