靶向药物制剂研究进展  

Research Advances in Targeted Drug Delivery System

作　　者：安琪 李爽 杨德智[1] 吕扬[1] 杜冠华[2] AN Qi;LI Shuang;YANG Dezhi;LYU Yang;DU Guanhua(Beijing Key Laboratory of Polymorphs Drugs Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]北京协和医学院中国医学科学院药物研究所晶型药物研究北京市重点实验室,北京100050 [2]北京协和医学院中国医学科学院药物研究所药物靶点研究与新药筛选北京市重点实验室,北京100050

出　　处：《医药导报》2024年第3期397-402,共6页Herald of Medicine

基　　金：国家自然科学基金面上项目(22278443);国家药品标准制修订研究课题(2022Y14);中国医学科学院医学与健康科技创新工程项目(2022-I2M-1-015)。

摘　　要：由于分子生物学、细胞生物学、材料科学等学科的飞速发展,靶向药物制剂成为近年来的研究热点。与普通药物制剂相比,靶向药物制剂可以选择性地提高靶组织中药物浓度,有效降低药物对正常组织的毒副作用,是一种较理想的给药方式。纳米材料以其在动物体内优越的性能受到更多的关注。纳米晶体在靶向药物制剂中的应用与发展有效改善了难溶性药物的开发瓶颈,在药物递送系统中发挥着不可或缺的作用。该文简要综述靶向制剂特点、分类,以及纳米晶体在药学领域的应用,可为靶向药物制剂的研究提供参考。In recent years,due to the development of disciplines such as molecular biology,cell biology,and materials science,the research of targeted therapy drugs has become a hot spot.Compared with conventional drugs,targeted therapy drugs can selectively increase the concentration and effectively reduce the toxic side effects of drugs in target tissues,which is an ideal way of drug delivery.Nanomaterial is receiving more attention for its superior performance in animals.The application and development of nanocrystals in targeted drug delivery systems has effectively broken the limitation of insoluble drugs and plays an indispensable role in drug delivery systems.In this paper,we briefly reviewed the characteristics and classification of targeted therapy drugs and the application of nanocrystals in pharmaceutical research to provide a reference for the related research.

关 键 词：靶向药物制剂 靶向药物 纳米晶体 难溶性药物 

分 类 号：TQ460.1[化学工程—制药化工]