筋骨痛消丸联合塞来昔布治疗膝骨关节炎临床研究  

Clinical Study on Jingu Tongxiao Pills Combined with Celecoxib for Knee Osteoarthritis

作　　者：李俊业 王冲 赵振杰 LI Junye;WANG Chong;ZHAO Zhenjie(The First Department of Neck,Shoulder,Waist and Leg Pain,Luoyang Orthopedic Traumatological Hospital of Henan Province(Henan Provincial Orthopedic Hospital),Luoyang Henan 471000,China;The Seventh Department of Spine Surgery,Luoyang Orthopedic Traumatological Hospital of Henan Province(Henan Provincial Orthopedic Hospital),Luoyang Henan 471000,China)

机构地区：[1]河南省洛阳正骨医院(河南省骨科医院)颈肩腰腿痛一科,河南洛阳471000 [2]河南省洛阳正骨医院(河南省骨科医院)脊柱外七科,河南洛阳471000

出　　处：《新中医》2023年第24期96-100,共5页New Chinese Medicine

摘　　要：目的:观察筋骨痛消丸联合塞来昔布对膝骨关节炎(KOA)的临床疗效。方法:将86例KOA患者随机分为研究组和对照组各43例。对照组应用塞来昔布治疗,研究组在对照组基础上加用筋骨痛消丸治疗。用药2个月后,评估2组临床疗效,比较2组治疗前后中医证候积分、疼痛数字评价量表(NRS)评分、膝关节屈曲与伸直最大角度、血清白细胞介素-1β (IL-1β)、白细胞介素-7 (IL-7)、成纤维细胞生长因子-2 (FGF-2)水平。结果:治疗后,研究组总有效率为93.02%,对照组为67.44%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分、NRS评分均较治疗前降低(P<0.05),且研究组中医证候积分、NRS评分均低于对照组(P<0.05)。治疗后,2组血清IL-1β、IL-7水平均较治疗前降低(P<0.05),FGF-2水平均较治疗前升高(P<0.05);且研究组IL-1β、IL-7水平低于对照组(P<0.05),FGF-2水平高于对照组(P<0.05)。治疗后,2组膝关节屈曲、伸直最大角度均较治疗前增大(P<0.05),且研究组膝关节屈曲、伸直最大角度均大于对照组(P<0.05)。结论:筋骨痛消丸联合塞来昔布治疗KOA疗效优于单用塞来昔布治疗,能显著改善患者临床症状,下调炎症因子水平,减轻关节损伤。Objective:To observe the clinical effect of Jingu Tongxiao Pills combined with Celecoxib on knee osteoarthritis(KOA).Methods:A total of 86 cases of KOA patients were randomly divided into the study group and the control group,with 43 cases in each group.The control group was treated with Celecoxib,and the study group was additionally treated with Jingu Tongxiao Pills based on the treatment of the control group.After 2 months of medication,clinical effects were evaluated in the two groups;traditional Chinese medicine(TCM) syndrome scores,the Numerical Rating Scale(NRS),maximum angles of knee joint flexion and extension,and the levels of interleukin-1β(IL-1β),interleukin-7(IL-7),and fibroblast growth factor-2(FGF-2) in serum were compared between the two groups before and after treatment.Results:After treatment,the total effective rate was 93.02% in the study group and 67.44% in the control group,the difference being significant(P<0.05).After treatment,TCM syndrome scores and NRS scores in the two groups were decreased when compared with those before treatment(P<0.05),and TCM syndrome score and NRS score in the study group were lower than those in the control group(P<0.05).After treatment,the levels of IL-1β and IL-7 in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of FGF-2 were increased when compared with those before treatment(P<0.05);the levels of IL-1β and IL-7 in the study group were lower than those in the control group(P<0.05),and the level of FGF-2 in the study group was higher than that in the control group(P<0.05).After treatment,the maximum angles of knee joint flexion and extension in the two groups were increased when compared with those before treatment(P<0.05),and the maximum angles of knee joint flexion and extension in the study group were larger than those in the control group(P<0.05).Conclusion:Jingu Tongxiao Pills combined with Celecoxib have better curative effect than the simple application of Celecoxib in the treatment of KOA,and can signi

关 键 词：膝骨关节炎 筋骨痛消丸 塞来昔布 成纤维细胞生长因子2 炎症因子 

分 类 号：R684.3[医药卫生—骨科学]