中度低钠血症患者的临床特点及治疗分析  

Clinical characteristics and treatment analysis of patients with moderate hyponatremia

作　　者：陈清[1,2] 李玉苗 江彦 黄爱文 CHEN Qing;LI Yu-miao;JIANG Yan;HUANG Ai-wen(Fuzong Clinical Medical College,Fujian Medical University,Fuzhou 350025,Fujian Province,China;Department of Clinical Pharmacy,900th Hospital of Joint Logistics Support Force,Fuzhou 350025,Fujian Province,China;School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,Fujian Province,China)

机构地区：[1]福建医科大学福总临床医学院,福建福州350025 [2]中国人民解放军联勤保障部队第九〇〇医院临床药学科,福建福州350025 [3]福建中医药大学药学院,福建福州350122

出　　处：《中国临床药理学杂志》2024年第3期350-353,共4页The Chinese Journal of Clinical Pharmacology

基　　金：福建医科大学启航基金资助项目(2020QH1251)。

摘　　要：目的 观察普通外科中度低钠血症患者的临床特点并分析其治疗效果。方法 将普通外科中度低钠血症患者按队列法分为对照组(不补充浓氯化钠注射液)和试验组(补充浓氯化钠注射液)。分析中度低钠血症患者的性别分布、年龄分布、营养状况、原发疾病等临床特点,对2组患者行倾向性评分匹配平衡混杂因素,使2组患者的基本情况可比,比较2组临床结局的差异。结果 共纳入227例患者,其中对照组82例,试验组145例。普通外科患者发生中度低钠血症的易患因素有男性、老年人、营养不良、肠外营养、恶性肿瘤。中度低钠血症患者经倾向性评分匹配后,对照组与试验组每组各73例患者。治疗后,试验组和对照组的总有效率分别为98.63%(72例/73例)和80.82%(59例/73例),纠正低钠血症需要时间分别为(3.54±1.90)和(3.97±2.54)d,在统计学上差异均有统计学意义(均P<0.05)。结论 应加强对普通外科中度低钠血症患者的关注,警惕发生重度低钠血症的风险。对于发生中度低钠血症患者,应给予浓氯化钠注射液治疗,以避免血钠水平进行性下降,从而提高疗效、改善预后。Objective To observe the clinical characteristics of patients with moderate hyponatremia in general surgery and analyze the efficacy.Methods Patients with moderate hyponatremia in general surgery were divided into control group(without supplemented concentrated sodium chloride injection) and treatment group(supplemented concentrated sodium chloride injection) according to the cohort method.The clinical characteristics of patients with moderate hyponatremia,such as gender distribution,age distribution,nutritional status,and primary disease were analyzed.Propensity score matching(PSM) was performed to balance confounding factors between the two groups,making their baseline conditions comparable and comparing the differences in clinical outcomes between the two groups.Results A total of 227 cases were included,including 82 in the control group and 145 in the treatment group.The predisposing factors of moderate hyponatremia in general surgery patients include male,elderly,malnutrition,parenteral nutrition,and malignant tumors.In addition,after PSM,there were 73 patients in each group of the control group and treatment group with moderate hyponatremia.The total effective rate of the control group was 80.82%,and correction of the hyponatremia takes time was(3.97±2.54).

关 键 词：浓氯化钠注射液 中度低钠血症 临床特点 治疗 普通外科 

分 类 号：R97[医药卫生—药品]