胃食管反流病与慢性阻塞性肺疾病:两样本孟德尔随机化研究  

Gastroesophageal reflux disease and chronic obstructive pulmonary disease:Two samples Mendelian randomization study

作　　者：张露 郭娜 郭鸿[2] 刘健 ZHANG Lu;GUO Na;GUO Hong;LIU Jian(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,Gansu Province,China;Department of Intensive Care Unit,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China;Department of Intensive Care Unit,Gansu Provincial Maternity and Child Health Hospital/Gansu Provincial General Hospital,Lanzhou 730000,Gansu Province,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院重症医学科,甘肃兰州730000 [3]甘肃省妇幼保健院、甘肃省中心医院重症医学科,甘肃兰州730000

出　　处：《中国临床药理学杂志》2024年第3期440-443,共4页The Chinese Journal of Clinical Pharmacology

基　　金：甘肃省自然科学基金资助项目(20YF8FA082)。

摘　　要：目的通过两样本孟德尔随机化方法,探讨胃食管反流病(GERD)和慢性阻塞性肺疾病(COPD)之间的因果关系。方法从全基因组关联研究(GWAS)汇总数据中筛选出与GERD相关的单核苷酸多态性(SNP)作为基因工具变量,主要分析采用逆方差加权法(IVW)来估计因果效应,用MR-Egger、加权中位数法、simple mode法和weighted mode法作为补充方法。为评估结果的稳健性,进行了敏感性分析,包括Cochran’s Q检验、MR-Egger截距和留一法。结果GERD可能与COPD风险增加有关[IVW:优势比(OR)=1.80,95%置信区间(confidence interval,CI)为1.55~2.08,P<0.01]。此外,MR-Egger截距、Cochran’s Q检验及留一法未观察到水平多效性和异质性。结论GERD可增加COPD风险,建议积极控制GERD以降低COPD的发生。Objective To explore the causal relationship between gastro esophageal reflux disease(GERD) and chronic obstructive pulmonary disease(COPD) by a two-sample Mendelian randomization method.Methods From the summary data of genome-wide association studies(GWAS),single nucleotide polymorphisms(SNP) associated with GERD were selected as genetic instrumental variables.The primary analysis employed the inverse variance weighted(IVW) method for estimating causal effects,with MR-Egger,weighted median,simple mode,and weighted mode methods as supplementary approaches.Sensitivity analyses were conducted to assess the robustness of the results,including Cochran's Q test,MR-Egger intercept,and leave-one-out analysis.Results There might be an association between GERD and an increased risk of COPD [IVW:odds ratio(OR)=1.80,95% confidence interval(CI) 1.55-2.08,P<0.01].Furthermore,no evidence of horizontal pleiotropy and heterogeneity was observed through MR-Egger intercept,Cochran's Q test,and leave-one-out analysis.Conclusion GERD can increase the risk of COPD,and aggressive control of GERD is recommended to reduce the incidence of COPD.

关 键 词：胃反流性食管炎 慢性阻塞性肺疾病 孟德尔随机化研究 

分 类 号：R97[医药卫生—药品]