高三酰甘油血症-腰围表型与中青年人群肌肉含量减少的相关性研究  

The relationship between hypertriglyceridemic-waist phenotype and muscle mass loss in the 18-65 year-old adults

作　　者：张晓会 刘芳[2] 刁英飞 李岳瀛 李艳玲[1] Zhang Xiaohui;Liu Fang;Diao Yingfei;Li Yueying;Li Yanling(Department of Nutrition,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Department of Preventive Treatment of Disease and Health Management Center,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心营养科,天津300381 [2]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心治未病健康管理中心,天津300381

出　　处：《中华内分泌代谢杂志》2023年第12期1045-1049,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的研究中青年人群肌肉含量减少的检出率,并探讨其相关影响因素。方法回顾性收集2019年3月至2021年10月于天津中医药大学第一附属医院治未病健康管理中心,年龄在18~65岁的中青年体检者1503名,收集一般资料及人体成分分析数据。以血三酰甘油≥1.7 mmol/L、腰围男性≥90 cm或女性≥85 cm为切点,将研究对象分为三酰甘油和腰围正常组、单纯高三酰甘油组、单纯腹型肥胖组、高三酰甘油血症-腰围表型(hypertriglyceridemic-waist phenotype,HTWC)组,比较4组间骨骼肌质量指数及相关指标差异。按年龄分4组,比较组间体成分差异。以是否肌肉含量减少为因变量,探索不同年龄不同性别中,HTWC表型是否为中青年人群肌肉含量减少的独立影响因素。结果HTWC组三酰甘油、空腹血糖、收缩压和舒张压均高于三酰甘油和腰围正常组,但其肌肉含量减少率低于其他3组(均P<0.001)。总体肌肉含量减少率为9.2%,男性为12.9%,女性为6.3%,男性为女性的2.05倍。18~35岁人群与56~65岁人群肌肉减少检出率相比,差异无统计学意义。多因素logistic回归分析显示,体重指数、体脂百分比、骨矿物质含量是18~45岁人群肌肉含量减少的独立影响因素。通过进一步校正混杂因素,HTWC表型仍不是肌肉含量减少的独立影响因素(OR=1.679,95%CI 0.523~5.386,P=0.384)。结论HTWC表型不是肌肉含量减少的独立影响因素。为预防中青年人群肌少症的发生,除评估四肢骨骼肌肌肉含量外,还应重视体重指数、骨矿物质含量和体脂百分比的检测。Objective To detect the incidence of muscle mass loss in the adults and explore its relevant influencing factors.Methods A total of 1503 participants aged between 18 and 65 years old were collected from the Department of Preventive Treatment of Disease and Health Management Center of First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from March 2019 to October 2021.All subjects completed physical and laboratory examination and bioelectrical impedance analysis.According to the cutpoint of plasma triglycerides concentration≥1.7 mmol/L,waist circumference≥85 cm in men or≥80 cm in women,1503 subjects were divided into four groups:normal triglycerides and waist circumference group,normal waist circumference and hypertriglyceridemia group,abdominal obesity and normal triglycerides group,and hypertriglyceridemic-waist phenotype(HTWC)group.Subjects were also divided into 4 groups according to age.Skeletal muscle mass index(ASMI)was calculated according to the skeletal muscle mass of the limbs.Differences of the ASMI and other relevant indicators among the above four groups were analyzed,and body composition was compared among four age groups.Then explore whether HTWC phenotype was an independent risk factor for the occurrence of sarcopenia in different age groups of different gender.Results The level of triglycerides,fasting blood glucose,systolic blood pressure,and diastolic blood pressure in HTWC group were higher than those in the normal group(all P<0.001).But the incidence of the muscle mass loss in the HTWC group was much lower than that in the other three groups(P<0.001).The incidence of muscle mass loss in overall subjects was 9.2%,in which man was 2.05 times higher than women(12.9%vs 6.3%).There is no statistically significant difference in the incidence of muscle mass loss between the 18-35 age group and the 56-65 age group.Multivariate logistic regression analysis revealed that body mass index,body fat percentage,bone mineral content were independent factors affecting muscle los

关 键 词：三酰甘油 腰围 肌少症 体重指数 体脂百分比 骨矿物质含量 

分 类 号：R589.2[医药卫生—内分泌]