肥胖对男性生殖健康影响的研究进展  

Obesity and male reproductive health:An update

作　　者：柒锐冰 陈冰 李争明 Qi Ruibing;Chen Bing;Li Zhengming(Department of Endocrinology and Metabolism,Wuming Hospital of Guangxi Medical University,Nanning 530199,China;Department of Endocrinology and Metabolism,Guangxi Academy of Medical Sciences and People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)

机构地区：[1]广西医科大学附属武鸣医院内分泌代谢科,南宁530199 [2]广西医学科学院,广西壮族自治区人民医院内分泌代谢科,南宁530021

出　　处：《中华内分泌代谢杂志》2023年第12期1083-1088,共6页Chinese Journal of Endocrinology and Metabolism

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题计划(Z20190904);广西自然科学基金面上项目(2020GXNSFAA297128)。

摘　　要：肥胖已成为一种日益严重的流行性疾病,严重影响人类生活质量。肥胖既增加了身体负担,还可能对身体各个系统和器官产生消极影响,如心血管系统和代谢系统。近年来,一些研究表明,肥胖还对生殖系统产生负面影响,影响男性生殖健康。男性生殖健康不仅关系到男性生殖功能正常与否,还关系到能否生育出健康的下一代。本文综述了肥胖对男性生殖健康影响的研究进展,包括内分泌激素紊乱、生殖器官结构破坏、氧化应激增加、生殖细胞表观遗传学改变,为更深入地了解肥胖对男性生殖的影响和治疗提供参考。Obesity has become a growing epidemic that seriously affects the quality of human life.Obesity not only adds the burden to the body but may have negative impacts on various body systems and organs,such as the cardiovascular and metabolic systems.In recent years,some studies have shown that obesity also negatively affects the reproductive system and influences male reproductive health.Male reproductive health is not only related to the normalization of male reproductive function but also plays a role in the ability to conceive healthy offspring.This article summarizes research progress on the effects of obesity on male reproductive health,including endocrine hormone disruption,reproductive organ structural damage,increased oxidative stress,and reproductive cell epigenetic alterations,providing insights for a deeper understanding of the influence of obesity on male reproduction and potential treatments.

关 键 词：肥胖 氧化应激 表观遗传 睾酮 瘦素 抑制素B 

分 类 号：R589.2[医药卫生—内分泌]