Development and performance evaluation of a culture-independent nanopore amplicon-based sequencing method for accurate typing and antimicrobial resistance profiling in Neisseria gonorrhoeae  

作　　者：Chi Zhang Lulu Zhang Feng Wang Yaling Zeng Liying Sun Di Wang Yamei Li Liqin Wang Junping Peng 

机构地区：[1]NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100176,China [2]Key Laboratory of Respiratory Disease Pathogenomics,Chinese Academy of Medical Sciences,Beijing 100730,China [3]Shenzhen Center for Chronic Disease Control,Shenzhen 518020,China

出　　处：《Science China(Life Sciences)》2024年第2期421-423,共3页中国科学（生命科学英文版）

基　　金：supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-037,2021-I2M-1-038);the National Natural Science Foundation of China(82002193);the National Science and Technology Infrastructure of China(National Pathogen Resource Center-NPRC-32);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019-PT310-029,2021-PT310-004);the Fundamental Research Funds for the Central Universities(3332021092)。

摘　　要：Dear Editor,Bacterial antimicrobial resistance(AMR)poses a serious threat to global human health(Antimicrobial Resistance Collaborators,2022).Comprehensive profiling of AMR and accurate molecular typing are important for tracking and controlling the emergence and dissemination of antibiotic-resistant bacteria(Yahara et al.,2021).We previously developed a multiplex amplicon sequencing-based method for directly sequencing AMR-related loci in N.gonorrhoeae from clinical samples(Zhang et al.,2021).

关 键 词：GONORRHOEAE resistance 

分 类 号：R759.2[医药卫生—皮肤病学与性病学]