以传染源控制为主的血吸虫病综合防治策略在血吸虫病传播控制推进阶段的实施效果  

Assessment of effectiveness of integrated schistosomiasis control strategywith emphasis on infectious source control in transmission control of schistosomiasisin China

作　　者：王帅 王浩[1] 刘聪[1] 罗华堂[1] WANG Shuai;WANG Hao;LIU Cong;LUO Hua-tang(Wuhan Center for Disease Control and Prevention,Wuhan,Hubei 430020,China)

机构地区：[1]武汉市疾病预防控制中心,湖北武汉430020

出　　处：《现代预防医学》2024年第3期536-541,共6页Modern Preventive Medicine

基　　金：湖北省卫健委联合项目(WJ2019H399)。

摘　　要：目的 分析1999—2015年我国以传染源控制为主的血吸虫病综合防治策略实施前后血吸虫病流行趋势变化,评估其在血吸虫传播控制推进过程中的实施效果。方法 收集1999—2015年全国血吸虫病疫情数据,应用中断时间序列(interrupted time series,ITS)方法分析以传染源控制为主的血吸虫病综合防治策略实施前后的人群血检阳性率、人群粪检阳性率、急性血吸虫感染病例数、存栏耕牛数、耕牛感染率变化。结果 以传染源控制为主的血吸虫病综合防治策略实施后,2005年急感病例数(β2=-937.433,P<0.001)和耕牛感染率(β2=-1.606,P=0.012)立即下降;策略实施后人群血检阳性率(β3=-1.164,P<0.001)、粪检阳性率(β3=-1.157,P<0.001)、急感病例数(β3=-143.939,P<0.001)、耕牛感染率(β3=-0.513,P=0.001)均呈现逐年下降趋势,对血吸虫病防控具有长期效果。结论 2006—2015年,我国人群血检阳性率、粪检阳性率、急感病例数、耕牛感染率呈现降低趋势,说明在我国血吸虫病传播控制推进阶段,以传染源控制为主的血吸虫病综合防治策略对控制血吸虫病流行具有显著效果。Objective To analyze the changes of schistosomiasis epidemic trend before and after the implementation of schistosomiasis integrated control strategy in China from 1999 to 2015,and to evaluate its effects in the process of schistosomiasis transmission control.Methods The epidemic data of schistosomiasis in China from 1999 to 2015 were collected,and the interrupted time series(ITS)method was used to analyze the changes of positive rate of blood test,positive rate of fecal test,number of acute schistosomiasis cases,number of cattle,and infection rate of cattle before and after the implementation of the comprehensive control strategy of schistosomiasis.Results After the implementation of the integrated schistosomiasis control strategy,the number of acute cases(β2=-937.433,P<0.001)and the infection rate of cattle(β2=-1.606,P=0.012)decreased immediately in 2005.After the implementation of the strategy,the positive rate of blood test(β3=-1.164,P<0.001),the positive rate of stool test(β3=-1.157,P<0.001),the number of acute cases(β3=-143.939,P<0.001),and the infection rate of cattle(β3=-0.513,P<0.001)showed a downward trend year by year,which had a long-term effect on the prevention and control of schistosomiasis.Conclusion From 2006 to 2015,the positive rate of blood test,the positive rate of stool test,the number of acute cases,and the infection rate of cattle in China showed a decreasing trend,indicating that in the advancing stage of schistosomiasis transmission control in China,the integrated schistosomiasis control strategy based on source of infection control has a significant effect on schistosomiasis control.

关 键 词：血吸虫病 传染源 综合防治 中断时间序列 

分 类 号：R532.21[医药卫生—内科学]