定量CT测量不同层面腰部椎后肌群体质成分的差异及相关性研究  

Difference and correlation of posterior vertebral muscle composition at different levels measured by quantitative computed tomography

作　　者：李新彤 姚宁 蔡韦 王玲 程晓光 LI Xin-tong;YAO Ning;CAI Wei;WANG Ling;CHENG Xiao-guang(Department of Radiology,Beijing Jishuitan Hospital,Capital Medical University,Beijing,100035,China)

机构地区：[1]首都医科大学附属北京积水潭医院放射科,北京100035

出　　处：《中国骨与关节杂志》2024年第2期113-117,共5页Chinese Journal of Bone and Joint

基　　金：国家自然科学基金青年项目(81901718);北京积水潭医院科研优才计划(JSTYC202207);北京积水潭医院院级科研基金(YGQ-202308)。

摘　　要：目的探讨腰部椎后肌群体质成分在L3及L5椎体层面的差异及相关性。方法对659名21~60岁的志愿者进行腰椎CT检查,包括276名男性及383名女性。使用定量CT获得L3及L5椎体层面椎后肌群的肌肉横截面积(cross-sectional muscle area,CSMA)、肌间隙脂肪面积(intra-muscular adipose area,IMAA)及肌肉脂肪浸润程度(muscle fat infiltration,MFI)。使用独立样本t检验比较男女间椎后肌群的差异。使用配对样本t检验比较两个层面椎后肌群的差异。使用person相关及线性回归分析L3、L5层面椎后肌群体质成分的相关关系。结果男性L3及L5层面椎后肌群CSMA大于女性(t=27.905、7.450,P<0.001),而MFI小于女性(t=-9.091、-11.755,P<0.001)。L3层面椎后肌群CSMA大于L5层面(t=55.850,P<0.001),而IMAA及MFI小于L5层面(t=-34.788、-57.774,P<0.001)。L3及L5层面的CSMA(r男性=0.459、r女性=0.365,P<0.01)、IMAA(r男性=0.336、r女性=0.325,P<0.01)、MFI(r男性=0.421、r女性=0.455,P<0.01)分别呈正相关,且回归方程均有统计学意义(P<0.001)。结论L3及L5层面椎后肌群体质成分存在差异及相关性,测量层面在必要时可以进行替代。Objective To investigate the difference and correlation of posterior vertebral muscle composition at L_(3) and L_(5) levels.Methods CT examination of the lumbar spine was performed in 659 volunteers aged 21-60 years,including 276 males and 383 females.Cross-sectional muscle area(CSMA),intra-muscular adipose area(IMAA),and muscle fat infiltration(MFI)of the posterior vertebral muscle at L_(3) and L_(5) levels were measured by quantitative computed tomography(QCT).An independent samples t-test was used to compare the muscle composition between males and females.The paired samples t-test was used to compare the muscle composition between two levels.Correlation analysis and linear regression analysis were used to determine the relationships of muscle composition between L_(3) and L_(5) levels.Results The CSMA at L_(3) and L_(5) levels in males was higher than that in females(t=27.905,7.450,P<0.001),and the MFI was lower than that in females(t=-9.091,-11.755,P<0.001).The CSMA at L_(3) level was higher than that at L_(5) level(t=55.850,P<0.001),while the IMAA and MFI were lower than that at L_(5) level(t=-34.788,-57.774,P<0.001).The CSMA(r=0.459,0.365,P<0.01),IMAA(r=0.336,0.325,P<0.01)and MFI(r=0.421,0.455,P<0.01)at L_(3) level were positively correlated with that at L5 level,respectively.All regression equations had statistical significance(P<0.001).Conclusions There are differences and correlations in the posterior vertebral muscle composition at L_(3) and L_(5) levels,and the measurement level can be replaced if necessary.

关 键 词：肌减少症 腰椎 锥束计算机体层摄影术 综合征 

分 类 号：R445[医药卫生—影像医学与核医学]