Antimicrobial roles of phagocytosis in teleost fish:Phagocytic B cells vs professional phagocytes  

作　　者：Liting Wu Lan Li Along Gao Jianmin Ye Jun Li 

机构地区：[1]Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture,Institute of Modern Aquaculture Science and Engineering,School of Life Sciences,South China Normal University,Guangzhou,510631,China [2]Guangdong Province Key Laboratory of Waterfowl Healthy Breeding,Zhongkai University of Agriculture and Engineering,Guangzhou,510225,China [3]School of Science and Medicine,Lake Superior State University,Sault Ste.Marie,MI,49783,USA

出　　处：《Aquaculture and Fisheries》2024年第2期105-114,共10页渔业学报（英文）

基　　金：supported by the National Natural Science Foundation of China(32102827,31972818,31528019);China Postdoctoral Science Foundation(2019M662959);Guangdong Basic and Applied Basic Research Foundation(2019A1515110987);Special fund for promoting economic development(for modern fishery development)of Guangdong Province(grant number 2019A4).

摘　　要：The defense system of teleost fish organized on innate and adaptive immunity protects them against a wide variety of pathogenic microorganisms in the aquatic environment.Phagocytosis is one of the most effective defense strategies against microbial challenge mainly performed by classical‘professional’phagocytes(including monocytes,macrophages and granulocytes).They contain,kill and process the internalized pathogens for antigen presentation by providing antigenic ligands to initiate activation and clonal expansion of T and B cells,which bridge the innate and adaptive immunity.The discovery of phagocytic B cells in teleost fish has broken the paradigm that primary vertebrate B cells are lack of phagocytosis of particulates,as well as led to the investigation of phagocytic activity of mammalian B-1 B cells.The active phagocytic,microbicidal capabilities and antigen presentation in teleost phagocytic B cell have demonstrated to be similar as professional phagocytes,providing a potential impact on development of new vaccination strategies to prevent and control infectious diseases.In this review,we aim to address current progress on the antimicrobial role of phagocytic B cells in teleost fish by comparing it with other professional phagocytes and mammalian B-1 B cells,and provide the application prospect of phagocytic B cells in developing vaccines as well as the prevention of fish diseases.

关 键 词：Teleost fish Phagocytic B cell PHAGOCYTOSIS Antimicrobial role Vaccine design 

分 类 号：Q95[生物学—动物学]