Design of polysaccharide gum based network copolymeric hydrogels for drug delivery and wound dressing applications  

作　　者：Baljit Singh Rajender Kumar Sushil Kumar Nistha Thakur Kaka Ram 

机构地区：[1]Department of Chemistry,Himachal Pradesh University,Shimla,171005,India

出　　处：《Medicine in Novel Technology and Devices》2023年第4期23-31,共9页医学中新技术与新装备（英文）

摘　　要：This article deals with the exploration of the design of network crosslinked structure by covalent bonding for use as wound dressing materials keeping in view inherent therapeutic role of neem gum in wound healing.These copolymeric hydrogels were prepared by graft-copolymerization reaction of carbopol and poly(N-vinylpyrrolidone)(poly(NVP).Antibiotic drug levofloxacin was encapsulated in dressings for better wound healing.The scanning electron microscopy(SEM),atomic force microscopy(AFM),Fourier transform infrared(FTIR)spectroscopy,^(13)C nuclear magnetic resonance(NMR)spectroscopy,X-ray diffraction(XRD),thermogravimetric analysis(TGA),differential thermal gravimetry(DTG),and differential scanning calorimetry(DSC)techniques were applied for characterization.NMR and FTIR demonstrated incorporation of carbapol and poly(NVP)in dressings.XRD indicated amorphous state in copolymeric dressings.Interactions of copolymers with drug,blood and bio membrane were studied to evaluate biomedical properties which revealed controlled release of drug from hydrogel dressings which were possessing blood-compatible(haemolytic value=2.4±0.82)and mucoadhesive(detachment force=124±41 mN)properties.Dressings were permeable to O2 and H2O vapour and absorbed 6.68±±0.62 g/g wound fluid which is ideal dressing characteristic.Diffusion mechanism type of drug levofloxacin was Fickian with kinetic model First order.These properties suggested use of hydrogel material for wound dressing and drug delivery applications for better wound care management.This article deals with the exploration of the design of network crosslinked structure by covalent bonding for use as wound dressing materials keeping in view inherent therapeutic role of neem gum in wound healing.These copolymeric hydrogels were prepared by graft-copolymerization reaction of carbopol and poly(N-vinylpyrrolidone)(poly(NVP).Antibiotic drug levofloxacin was encapsulated in dressings for better wound healing.The scanning electron microscopy(SEM),atomic force microscopy(AFM),Fourier

关 键 词：GRAFT-COPOLYMERIZATION Hydrogel wound dressing LEVOFLOXACIN Neem gum Drug delivery 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]