奥硝唑辅助牙周基础治疗在2型糖尿病伴慢性牙周炎中的效果及对炎症因子的影响  

Effect of Periodontal Basic Therapy in Patients with Type 2 Diabetes Mellitus Complicated with Chronic Periodontitis and Its Influence on Inflammatory Factors

作　　者：谢红霞 尹佐林 XIE Hongxia;YIN Zuolin(Department of Stomatology,Guangdong Provincial People's Hospital Ganzhou Hospital,Ganzhou 341000,China;不详)

机构地区：[1]广东省人民医院赣州医院(赣州市立医院)口腔科,江西赣州341000

出　　处：《中国医学创新》2024年第5期60-64,共5页Medical Innovation of China

摘　　要：目的:探讨奥硝唑辅助牙周基础治疗在2型糖尿病伴慢性牙周炎患者中的效果及对炎症因子的影响。方法:选取2020年2月—2022年2月在广东省人民医院赣州医院进行治疗的78例2型糖尿病伴慢性牙周炎患者,按随机数字表法分为基础组(n=39)与观察组(n=39)。基础组采取牙周基础治疗,观察组在基础组上加以奥硝唑进行治疗。比较两组临床疗效、炎症因子、骨保护素(OPG)、牙周指标及氧化应激指标。结果:治疗前,两组白细胞介素-21(IL-21)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、OPG、菌斑指数(PLI)、龈沟出血指数(SBI)、探诊深度(PD)、临床附着水平(CAL)、活性氧(ROS)、丙二醛(MDA)、超氧化物歧化酶(SOD)比较,差异均无统计学意义(P>0.05);治疗后,观察组治疗总有效率、OPG、SOD均高于基础组,IL-21、IL-17、TNF-α、PLI、PD、ROS、MDA均低于基础组,差异均有统计学意义(P<0.05)。结论:对2型糖尿病伴慢性牙周炎患者予以奥硝唑联合牙周基础治疗具有较好临床效果,能减轻炎症反应及氧化应激反应,改善牙周组织状态。Objective:To investigate the effect of periodontal basic therapy in patients with type 2 diabetes mellitus complicated with chronic periodontitis and its influence on inflammatory factors.Method:A total of 78 patients with type 2 diabetes mellitus complicated with chronic periodontitis treated in Guangdong Provincial People's Hospital Ganzhou Hospital from February 2020 to February 2022 were selected and divided into basic group(n=39)and observation group(n=39)according to random number table method.The basic group was treated with periodontal basic therapy,and the observation group was treated with Ornidazole on the basis of the basic group.The clinical efficacy,inflammatory factors,osteoprotegerin(OPG),periodontal indexes and oxidative stress indexes were compared between the two groups.Result:Before treatment,there were no significant differences in interleukin-21(IL-21),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),OPG,plaque index(PLI),sulcus bleeding inde(SBI),probing depth(PD),clinical attachment level(CAL),reactive oxygen species(ROS),malondialdehyde(MDA)and superoxide disgum(SOD)between the two groups(P>0.05).After treatment,the total effective rate,OPG and SOD in observation group were higher than those in basic group,IL-21,IL-17,TNF-α,PLI,PD,ROS and MDA in observation group were lower than those in basic group,the differences were statistically significant(P<0.05).Conclusion:Ornidazole combined with periodontal basic therapy has a good clinical effect on patients with type 2 diabetes mellitus complicated with chronic periodontitis,which can reduce inflammatory reaction and oxidative stress reaction and improve periodontal tissue status.

关 键 词：奥硝唑 牙周基础治疗 2型糖尿病 慢性牙周炎 炎症因子 

分 类 号：R587.1[医药卫生—内分泌] R781.42[医药卫生—内科学]