肠道激素PYY在肥胖和2型糖尿病中的研究进展  

Research Progress of Intestinal Hormone PYY in Obesity and Type 2 Diabetes Mellitus

作　　者：郭小佩 刘清泉 刘德胜 郑瑞 陈会 GUO Xiaopei;LIU Qingquan;LIU Desheng;ZHENG Rui;CHEN Hui(Xi’an Medical University,Xi’an 710021,China;不详)

机构地区：[1]西安医学院,陕西西安710021 [2]空军军医大学唐都医院内分泌科,陕西西安710038

出　　处：《中国医学创新》2024年第5期180-185,共6页Medical Innovation of China

基　　金：军队保健课题(20BJZ12)。

摘　　要：2型糖尿病是以胰岛素抵抗为病理基础的慢性代谢性疾病,在糖尿病人群中的占比超过90%,目前在世界范围内影响深广,数以亿计的患者深受其害。肥胖作为2型糖尿病的重要危险因素之一,在糖尿病的发生发展及治疗预后中有着举足轻重的作用。随着生活水平的提升,肥胖合并2型糖尿病的患者在糖尿病人群中占比增高,现有治疗手段不能满足日益增长的需求。寻找新的降糖且减重的方法治疗2型糖尿病也被提上日程,肠道激素被发现在体重减轻与胰岛功能改善中发挥重要作用,其中酪酪肽(PYY)成为近年的研究热点。本文将围绕肠道激素PYY减轻体重、改善糖尿病方面做一综述,为2型糖尿病的治疗提供新的思路。Type 2 diabetes mellitus is a chronic metabolic disease on the pathological basis of insulin resistance,accounting for more than 90%of the diabetes population.At present,it has a profound influence in the world,and hundreds of millions of patients suffer from it.Obesity,as one of the important risk factors of type 2 diabetes mellitus,plays an important role in the occurrence,development,treatment and prognosis of diabetes.With the improvement of living standards,the proportion of obese patients with type 2 diabetes mellitus in diabetes population has increased,and the existing treatment methods can not meet the growing demand.Finding new ways to reduce blood sugar and weight has also been put on the agenda to treat type 2 diabetes mellitus,and intestinal hormones have been found to play an important role in weight loss and improvement of islet function,among which peptide YY(PYY)has become a research hotspot in recent years.This article will focus on the intestinal hormone PYY to reduce weight and improve diabetes provides an overview,and provide new ideas for the treatment of type 2 diabetes mellitus.

关 键 词：2型糖尿病 肥胖 酪酪肽 肠道激素 糖脂代谢紊乱 

分 类 号：R587.1[医药卫生—内分泌]