局部外用小分子药物治疗斑秃的研究进展  

Research Progress of Topical Small Molecule Drugs in Treating Alopecia Areata

作　　者：韩君雅 吴维维 祝文文 方险峰[1] HAN Junya;WU Weiwei;ZHU Wenwen;FANG Xianfeng(Department of Dermatology and Venereology,the First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China;不详)

机构地区：[1]三峡大学第一临床医学院(宜昌市中心人民医院)皮肤性病科,湖北宜昌443003

出　　处：《中国医学创新》2024年第5期185-188,共4页Medical Innovation of China

摘　　要：斑秃(AA)是一种常见的毛囊自身免疫性疾病,外用药物的应用对轻中度AA具有重要作用。传统局部外用药物,如糖皮质激素、米诺地尔、局部刺激剂等对于部分患者仍缺乏满意疗效,且长期使用受到副作用的限制。随着对AA发病机制的进一步了解,酪氨酸蛋白激酶(JAK)抑制剂、磷酸二酯酶抑制剂等小分子药物给斑秃的治疗带来了新的希望。目前仍需要更多研究证明其有效性及安全性。Alopecia areata(AA)is a common autoimmune disease of hair follicles,the application of topical drugs plays an important role in mild to moderate AA.Traditional topical drugs such as Glucocorticoids,Minoxidil,topical contact irritants,etc.lack satisfactory efficacy for some patients,and long-term use is limited by side effects.With the further understanding of the pathogenesis of AA,small molecule drugs such as JAK inhibitors and phosphodiesterase inhibitors have brought available treatment for alopecia areata.More researches are needed to prove its efficacy and safety.

关 键 词：斑秃 外用药物 酪氨酸蛋白激酶抑制剂 磷酸二酯酶抑制剂 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]