疏肝活血法治疗慢性前列腺炎临床疗效的Meta分析  

Meta-analysis of the clinical eficacy of Shugan Huoxue Therapy in the treatment of chronic prostatitis

作　　者：陈颖雯 郑青霞 文证 张泽政 陈树超 傅伟 李其信 CHEN Yingwen;ZHENG Qingxia;WEN Zheng;ZHANG Zezheng;CHEN Shuchao;FU Wei;LI Qixin(Department of Andrology,Bao′an Traditional Chinese Medicine Hospital(the Seventh Clinical Medical College of Guangzhou University of Traditional Chinese Medicine),Shenzhen 518133,Guangdong,China)

机构地区：[1]广州中医药大学附属宝安中医院(广州中医药大学第七临床医学院)男科,广东深圳518133

出　　处：《中国性科学》2024年第2期147-152,共6页Chinese Journal of Human Sexuality

基　　金：广东省基层老中医药专家传承工作室建设项目(粤中办函[2020]1号);广东省科技计划项目(2016A020215198)。

摘　　要：目的综合评价疏肝活血类中药治疗慢性前列腺炎的临床作用,以期为中医药防治慢性前列腺炎提供新思路及可靠依据。方法检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed建库至2023年2月收录的采用疏肝活血类中药治疗慢性前列腺炎的临床随机对照试验研究,应用RevMan 5.4软件对根据纳入排除标准筛选出的10篇文献进行Meta分析。结果Meta结果显示,与单纯使用西药/中成药相比,采用疏肝活血法干预的临床疗效总有效率是对照组的1.26倍(RR=1.26,95%CI:1.19~1.34,P<0.00001);慢性前列腺炎症状指数(NIH-CPSI)评分显著降低(MD=-4.75,95%CI:-5.56~-3.94,P<0.00001);疼痛(或不适)症状有效缓解(MD=-1.23,95%CI:-1.96~-0.50,P=0.0009);排尿症状改善(MD=-1.03,95%CI:-1.45~-0.61,P<0.00001);生活质量提高(MD=-1.18,95%CI:-1.29~-1.07,P<0.00001)。结论采用疏肝活血类中药治疗慢性前列腺炎,其总有效率、NIP-CPSI评分降低程度、疼痛(或不适)症状的缓解程度、排尿症状的改善及生活质量的提高明显优于单纯应用西药/中成药。Objective To comprehensively evaluate the clinical effects of traditional Chinese medicine(TCM)herbs of Shugan Huoxue in the treatment of chronic prostatitis,with the aim of providing new ideas and reliable basis for TCM prevention and treatment of chronic prostatitis.Methods The clinical randomized controlled trial studies in the treatment of TCM herbs for Shugan Huoxue were searched in CNKI,Wanfang,VIP,CBM and PubMed from the establishment of the database to February 2023.Meta-analysis of the 10 papers screened in accordance with the inclusion and exclusion criteria was performed with RevMan 5.4 software.Results The Meta results showed that,compared with the use of western/Chinese patent medicine alone,the total effective rate of clinical efficacy of interventions using the Shugan Huoxue Therapy was 1.26 times that of the control group(RR=1.26,95%CI:1.19-1.34,P<0.000,01).The national institute of health chronic prostatitis symptom index(NIH-CPSI)score was significantly reduced(MD=-4.75,95%CI:-5.56--3.94,P<0.000,01).Pain(or discomfort)symptoms was effective mitigated(MD=-1.23,95%CI:-1.96--0.50,P=0.000,9).Urinary symptoms were improved(MD=-1.03,95%CI:-1.45--0.61,P<0.000,01).Quality of life was improved(MD=-1.18,95%CI:-1.29--1.07,P<0.000,01).Conclusions In the treatment of chronic prostatitis,the total effective rate,the reduction of NIP-CPSI score,the relief of pain(or discomfort)symptoms,the improvement of urinary symptoms and the improvement of quality of life were significantly superior in using of TCM herbs of Shugan Huoxue than western/Chinese patent medicine alone.

关 键 词：疏肝活血 慢性前列腺炎 临床疗效 META分析 

分 类 号：R697[医药卫生—泌尿科学]