细化生活方式联合屈螺酮炔雌醇片(Ⅱ)、二甲双胍治疗多囊卵巢综合征合并高胆固醇血症不孕症患者的临床效果及对Betatrophin水平的影响  

Clinical effect of refined lifestyle combined with Drospirenone Ethinyl Estradiol Tablets(Ⅱ)and Metformin in the treatment of polycystic ovary syndrome with hypercholesterolemia infertility and its influence on Betatrophin level

作　　者：司凡[1] 孙萌 陈妍[1] 陆宏燕 寇伟鑫[1] 许丽丽 SI Fan;SUN Meng;CHEN Yan;LU Hongyan;KOU Weixin;XU Lili(Department of Reproductive Medicine,Chengde Central Hospital,Hebei Province,Chengde 067000,China;Departmentof of Health Education,Chengde Center for Disease Control and Prenvention,Hebei Province,Chengde 067000,China)

机构地区：[1]河北省承德市中心医院生殖医学科,河北承德067000 [2]河北省承德市疾病预防控制中心健康教育科,河北承德067000

出　　处：《妇儿健康导刊》2024年第2期28-31,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

基　　金：河北省承德市科技计划项目(202102A004)。

摘　　要：目的探讨细化生活方式联合屈螺酮炔雌醇片(Ⅱ)、二甲双胍治疗多囊卵巢综合征(PCOS)合并高胆固醇血症不孕症患者的临床效果及对Betatrophin水平的影响。方法选择2021年1月至8月在河北省承德市中心医院生殖医学科确诊的30例PCOS合并高胆固醇血症不孕症患者,根据不同治疗方案分为A组和B组,各15例。A组给予平衡膳食、运动管理联合屈螺酮炔雌醇片(Ⅱ)和二甲双胍治疗,B组给予屈螺酮炔雌醇片(Ⅱ)和二甲双胍治疗。比较两组的体重指数、总胆固醇、性激素及血清Betatrophin水平、排卵和妊娠情况。结果治疗后A组体重指数、总胆固醇、黄体生成素、雄烯二酮、Betatrophin水平低于B组(P<0.05);两组排卵、临床妊娠率比较,差异无统计学意义(P>0.05)。结论细化生活方式联合屈螺酮炔雌醇片(Ⅱ)、二甲双胍治疗PCOS合并高胆固醇血症不孕症患者,可有效改善脂代谢紊乱,降低黄体生成素、雄烯二酮、血清Betatrophin水平。Objective To investigate the clinical effect of refined lifestyle combined with Drospirenone Ethinyl Estradiol Tablets(Ⅱ)and Metformin in the treatment of polycystic ovary syndrome(PCOS)with hypercholesterolemia infertility and its influence on Betatrophin level.Methods A total of 30 patients with PCOS and hypercholesterolemia infertility diagnosed in the Department of Reproductive Medicine of Chengde Central Hospital,Hebei Province from January to August 2021 were selected.According to different treatment regimens,they were divided into group A and group B,15 cases in each group.Group A was treated with balanced diet,exercise management combined with Drospirenone Ethinyl Estradiol Tablets(Ⅱ)and Metformin,and group B was treated with Drospirenone Ethinyl Estradiol Tablets(Ⅱ)and Metformin.The body mass index,total cholesterol,sex hormones and serum Betatrophin levels,ovulation and pregnancy were compared between the two groups.Results After treatment,the body mass index,total cholesterol,luteinizing hormone,androstenedione and Betatrophin levels in group A were lower than those in group B(P<0.05).There was no significant difference in ovulation and clinical pregnancy rate between the two groups(P>0.05).Conclusion Refined lifestyle combined with Drospirenone Ethinyl Estradiol Tablets(Ⅱ)and Metformin in the treatment of PCOS with hypercholesterolemia infertility can effectively improve lipid metabolism disorders and reduce the levels of luteinizing hormone,androstenedione and serum Betatrophin.

关 键 词：细化生活方式 屈螺酮炔雌醇片(Ⅱ) 二甲双胍 多囊卵巢综合征 高胆固醇血症 不孕症 Betatrophin水平 妊娠情况 

分 类 号：R711.6[医药卫生—妇产科学]