阶梯式治疗与早期胰岛素强化治疗2型糖尿病的效果比较  

Effect comparison of ladder therapy and early intensive insulin therapy for type 2 diabetes

作　　者：张琳琳 ZHANG Linlin(Department of Endocrinology,Liaoning Health Industry Group Iron Coal General Hospital,Liaoning Province,Tieling 112700,China)

机构地区：[1]辽宁省健康产业集团铁煤总医院内分泌科,辽宁铁岭112700

出　　处：《中国当代医药》2024年第4期78-81,共4页China Modern Medicine

摘　　要：目的将阶梯式治疗与早期胰岛素强化治疗2型糖尿病的效果及对其血糖血脂水平、胰岛功能及不良反应发生率的影响进行对照分析。方法选取2021年11月至2022年10月辽宁省健康产业集团铁煤总医院内分泌科收治的80例2型糖尿病患者作为研究对象,按照随机数字表法分为研究组(40例)与常规组(40例),常规组采用阶梯式治疗方案,研究组采用接受早期胰岛素强化治疗。比较两组患者的血糖水平、血脂水平、胰岛功能及不良反应发生率。结果两组患者不良反应总发生率比较,差异无统计学意义(P>0.05);研究组的血糖水平、血脂水平低于常规组,差异有统计学意义(P<0.05);研究组的HOMA-β水平高于常规组,研究组HOMA-IR水平低于常规组,差异有统计学意义(P<0.05)。结论对2型糖尿病患者给予早期胰岛素强化治疗可有效控制患者血糖水平,使其胰岛功能得到了有效的改善。Objective The effects of ladder therapy and early intensive insulin therapy on blood glucose and lipid levels,islet function and the incidence of adverse reactions in type 2 diabetes were compared.Methods A total of 80 patients with type 2 diabetes admitted to the Department of Endocrinology,Liaoning Health Industry Group Iron Coal General Hospital from November 2021 to October 2022 were selected as the study objects,and they were divided into study group(40 cases)and routine group(40 cases)according to random number table method.The routine group received ladder therapy,and the study group received early intensive insulin therapy.The blood glucose level,lipid level,islet function and the incidence of adverse reactions were compared between the two groups.Results There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).The blood glucose level and blood lipid level of the study group were lower than those of the routine group,and the differences were statistically significant(P<0.05).The level of HOMA-βin the study group was higher than that in the routine group,and the level of HOMA-IR in the study group was lower than that in the routine group,with statistical significances(P<0.05).Conclusion Early intensive insulin therapy for type 2 diabetes can effectively control the blood glucose level and improve the islet function effectively.

关 键 词：早期胰岛素强化治疗 2型糖尿病 空腹血糖 餐后2 h血糖水平 

分 类 号：R587.1[医药卫生—内分泌]