加味茵陈蒿汤直肠滴入治疗黄疸型病毒性肝炎肝胆湿热证对患者肝功能及炎症指标的影响  

Effects of rectal instillation of flavored Yinchenhao Decoction on liver function and inflammatory indexes in the treatment of hepatobiliary humid fever jaundice

作　　者：吕婕 李姗 王强 LYU Jie;LI Shan;WANG Qiang(Department of Hepatology,Jiujiang Traditional Chinese Medicine Hospital,Jiangxi Province,Jiujiang332000,China)

机构地区：[1]江西省九江市中医医院肝病科,江西九江332000

出　　处：《中国当代医药》2024年第5期34-38,共5页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2022B094);江西省九江市级指导性科技计划项目(S2022ZDYFN339)。

摘　　要：目的探讨在黄疸型病毒性肝炎肝胆湿热证中以加味茵陈蒿汤直肠滴入治疗的临床效果,并针对该治疗方法对患者肝功能及炎症指标的影响进行分析。方法回顾性分析2022年1月至2023年2月九江市中医医院收治的80例肝胆湿热型黄疸患者的临床资料,按照不同治疗方案将其分为对照组(40例)与观察组(40例),对照组给予利胆退黄、保肝抗炎、营养支持等对症治疗,观察组在此基础上加用加味茵陈蒿汤直肠滴入治疗,比较两组患者临床疗效及治疗前后肝功能、中医证候积分及炎症指标等情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,观察组中医证候(黄疸、发热、恶心呕吐、大便干结、口干及纳呆)评分及炎症指标超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)水平低于对照组,两组治疗后肝功能指标总胆红素(TBil)、结合胆红素(DBil)、谷丙转氨酶(ALT)、天冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)及碱性磷酸酶(ALP)指标水平低于本组治疗前,差异有统计学意义(P<0.05);观察组治疗后总胆红素(TBil)、直接胆红素(DBil)、谷氨酰胺转移酶(GGT)指标水平低于对照组,差异有统计学意义(P<0.05)。结论将加味茵陈蒿汤采用直肠滴入的治疗方式能够有效改善黄疸型病毒性肝炎肝胆湿热证患者肝功能,降低其炎症反应,具有较好治疗效果,为临床提供更多有效治疗手段。Objective To investigate the clinical effect of rectal instillation of flavored Yinchenhao Decoction in hepatobiliary moist jaundice,and to analyze the effects of this treatment on liver function and inflammatory indexes.Methods A total of 80 patients diagnosed with hepatobiliary humid fever jaundice in Jiujiang Hospital of Traditional Chinese Medicine from January 2022 to February 2023 were grouped according to different treatment regimens,each group was 40 cases,among which the control group was given symptomatic treatment such as choleretic and yellowing,hepatoprotective and anti-inflammatory,nutritional support,etc.,and the treatment group was treated with rectal instillation with flavored Yinchenhao Decoction,and the clinical efficacy and liver function,traditional Chinese medicine(TCM)dialectical score and inflammatory indexes before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of TCM syndrome(jaundice,fever,nausea and vomiting,dry stool,dry mouth and nerdness)and the levels of inflammatory indicators hypersensitive C-reactive protein(hs-CRP),tumor necrosis factorα(TNF-α)and interleukin-6(IL-6)in the observation group were lower than those in the control group,and the total bilirubin(TBil),direct bilirubin(DBil),alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl transpeptidase(GGT)and alkaline phosphatase(ALP)were lower compared with the pre-treatment,and the differences were statistically significant(P<0.05).The TBil,DBil and GGT in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The treatment method of rectal infusion of flavored Yinchenhao Decoction can effectively improve the liver function of patients with hepatobiliary humid fever jaundice,reduce their inflammatory response,have good therape

关 键 词：加味茵陈蒿汤 直肠滴入 肝胆湿热 黄疸 

分 类 号：R512.6[医药卫生—内科学]