柴胡-白芍配伍抗抑郁药理作用机制研究进展  

Research progress on antidepressant pharmacological effects and mechanisms of Bupleuri Radix⁃Paeoniae Radix Alba herb⁃pair

作　　者：蔡康林 张婧恺 冉亮弟 胡大军[1] 冯知涛 黄慧莲 CAI Kanglin;ZHANG Jinkai;RAN Liangdi;HU Dajun;FENG Zhitao;HUANG Huilian(The Second People′s Hospital Affiliated to China Three Gorges University/Yichang Second People′s Hospital,Yichang 443000,China;College of Basic Medicine Sciences,China Three Gorges University,Yichang 443003,China;不详)

机构地区：[1]三峡大学附属第二人民医院/宜昌市第二人民医院,湖北宜昌443008 [2]三峡大学基础医学院,湖北宜昌443002 [3]三峡大学健康医学院,湖北宜昌443002

出　　处：《实用医学杂志》2024年第4期447-452,共6页The Journal of Practical Medicine

基　　金：湖北省医学青年拔尖人才(编号:鄂卫通[2023]65)。

摘　　要：抑郁症是一种常见的精神障碍,严重影响患者生存质量。目前临床西药治疗抑郁症效果不理想,需寻求新的抗抑郁药物及靶点。柴胡-白芍作为抗抑郁复方的核心和重要组成部分,两者配伍使用具有减毒增效抗抑郁作用,其机制可能与抑制炎症与氧化应激、调节单胺类神经递质、脑源性神经营养因子水平,影响下丘脑-垂体-肾上腺轴、多种氨基酸代谢和能量代谢等有关。本文通过综述柴胡-白芍配伍的协同效应以及抗抑郁药理作用,以期为阐明柴胡-白芍的配伍优势以及抗抑郁的作用机制提供参考。Depression is a frequently⁃seen mental disorder that profoundly affects the survival and quality of life of individuals.Present clinical medicine therapies for depression are not fully efficacious and novel therapeutic agents and targets remain necessary.Bupleuri Radix⁃Paeoniae Radix(BR⁃PRA),an essential and crucial compo⁃nent of traditional antidepressant compound,possesses the beneficial effect of lowering toxicity and amplifying the antidepressant effect when utilized in combination.The underlying mechanisms of these synergistic effects may involve the suppression of inflammation and oxidative stress,the regulation of monoamine neurotransmitters,brain⁃derived neurotrophic factors,the modulation of the hypothalamus⁃pituitary⁃adrenal axis,and the metabolism of various amino acids and energy.This article summarizes the synergistic effects and antidepressant pharmacological effects of BR⁃PRA herb⁃pair,thereby providing valuable insights into the potential advantages of this combination and its potential mechanisms of antidepressant action.

关 键 词：柴胡-白芍 药对 抑郁 炎症反应 氧化应激 

分 类 号：R285[医药卫生—中药学] R277.7[医药卫生—中医学]