基于MRI分析阿尔茨海默病大尺度脑网络研究进展  

Research progress of large-scale brain network of Alzheimer’s disease based on MRI analysis

作　　者：韩英妹 李一杰 张衡 吕静 张仪 乔英博 林楠 徐慧勇 王丰[2] HAN Ying-mei;LI Yijie;ZHANG Heng;LV Jing;ZHANG Yi;QIAO Yingbo;LIN Nan;XU Huiyong;WANG Feng(Gradu-ate School of Heilongjiang University of Chinese Medicine,Harbin 150040,China;不详)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第一医院CT磁共振科,哈尔滨150040

出　　处：《实用医学杂志》2024年第4期575-579,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金面上项目(编号:81973930);黑龙江省自然科学基金资助项目(编号:LH2023H065)。

摘　　要：随着老龄化时代的到来,阿尔茨海默病(Alzheimer’s disease,AD)逐渐成为困扰老年人的主要疾病。AD是一种与认知功能障碍相关的神经退行性疾病,在AD患者中,大脑网络连接遭到破坏,同时其拓扑属性也受到影响,导致解剖和功能连接的耦合分解。解剖连接可通过结构磁共振和弥散张量成像来追踪和评估;而功能连接则基于功能磁共振成像来检测其连接情况。本文借鉴以往学者的研究成果,总结AD的研究现状,旨在讨论AD患者大尺度脑网络改变的影像学特征,为广大研究者提供科学客观的AD预测及早期诊断的影像学标志物,以及未来研究思路。With the advent of an aging society,Alzheimer′s disease(AD)has gradually become a major ailment affecting the elderly.AD is a neurodegenerative disorder associated with cognitive impairments.In AD patients,brain network connections are disrupted,and their topological properties are also affected,leading to the disintegration of anatomical and functional connections.Anatomical connections can be tracked and evaluated using structural magnetic imaging(MRI)and diffusion tensor imaging(DTI),while functional connections are detected through functional MRI to assess their connectivity status.This review incorporates the findings of previous scholars and summarizes the current research of AD.It mainly discusses the imaging characteristics of large-scale brain network changes in AD patients,so as to provide researchers with scientific and objective imaging markers for AD prediction and early diagnosis,as well as future research.

关 键 词：阿尔茨海默病 脑网络 功能磁共振 功能连接 小世界属性 

分 类 号：R338.2[医药卫生—人体生理学]