血清C1q/肿瘤坏死因子相关蛋白9水平与妊娠期糖尿病及其胰岛素抵抗的关系  

Serum levels of C1q/TNF-related protein 9 and its association with insulin resistance in gestational diabetes mellitus

作　　者：刘瑜婷 石敏[1] 陈燕娜 尹路路 胡长军[1] LIU Yuting;SHI Min;CHEN Yanna;YIN Lulu;HU Changjun(Department of Endocrinology,the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University,Huai'an,Jiangsu 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院内分泌科,江苏淮安223300

出　　处：《中华全科医学》2024年第2期195-197,229,共4页Chinese Journal of General Practice

基　　金：国家自然科学基金青年科学基金项目(81700723)。

摘　　要：目的探讨妊娠期糖尿病(GDM)孕妇血清C1q/肿瘤坏死因子相关蛋白9(CTRP9)的表达水平及其应用价值。方法选取2019年10月—2020年10月在淮安市第一人民医院就诊的35名GDM患者(GDM组)和37名健康孕妇(对照组)。比较2组孕妇的一般资料、糖代谢指标、CTRP9及其他脂肪因子水平,并通过Pearson相关分析研究脂肪因子与GDM患者临床指标的相关性。结果GDM组空腹血糖(FPG)、口服葡萄糖耐量试验(OGTT)1 h血糖(1hPG)、2 h血糖(2hPG)、空腹胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)、白介素-6(IL-6)、瘦素(leptin)、肿瘤坏死因子-α(TNF-α)、CTRP9水平均高于正常对照组(P<0.05)。Pearson相关分析显示:血清CTRP9与FPG、1hPG、2hPG、FINS、HOMA-IR、IL-6和TNF-α均呈正相关关系(P<0.05)。Logistic回归分析显示升高的HOMA-IR(OR=14.771,P=0.046)和CTRP9(OR=4.965,P=0.002)是GDM发生的独立危险因素。ROC分析显示,CTRP9、HOMA-IR诊断GDM的曲线下面积分别为0.914和0.822;二者联合检测的曲线下面积为0.943,诊断效能最佳。结论GDM孕妇血清中CTRP9水平升高,CTRP9升高是GDM发生的独立危险因素。CTRP9联合HOMA-IR筛查GDM的价值优于单一指标。Objective To investigate the relationship between serum C1q/tumor necrosis factor-related protein 9(CTRP9)and gestational diabetes mellitus(GDM)and its clinical significance.Methods A total of 35 patients with GDM and 37 pregnant women without the condition were enrolled.The general characteristics,glucose metabolism indicators,serum CTRP9 levels and other adipokine levels were compared between the two groups.In addition,a Pearson correlation analysis was conducted to examine the correlation between serum CTRP9,other cytokines and clinical indexes in pregnant women with GDM.Results The fasting plasma glucose(FPG),OGTT 1hPG,OGTT 2hPG,fasting insulin(FINS),HOMA-IR,interleukin-6(IL-6),leptin,tumor necrosis factor-α(TNF-α),and CTRP9 in the GDM group were higher than those in the control group(P<0.05).The results of the Pearson correlation analysis indicated that serum CTRP9 was positively correlated with FPG,1hPG,2hPG,FINS,HOMA-IR,IL-6 and TNF-α(P<0.05).The logistic regression analysis showed that elevated HOMA-IR(OR=14.771,P=0.046)and CTRP9(OR=4.965,P=0.002)were independent risk factors for GDM.ROC analysis demonstrated that CTRP9 and HOMA-IR had areas under the curve of 0.914 and 0.822,respectively,for diagnosing GDM.The combined detection had an area under the curve of 0.943,indicating optimal diagnostic efficiency.Conclusion The serum CTRP9 level is elevated in GDM.Elevated serum CTRP9 level is an independent risk factor for GDM.Furthermore,the combination of serum CTRP9 and HOMA-IR was more efficient in screening for GDM.

关 键 词：妊娠期糖尿病 C1q/肿瘤坏死因子相关蛋白9 脂肪因子 胰岛素抵抗 

分 类 号：R714.256[医药卫生—妇产科学]