试析盐酸氨溴索与多巴胺联合治疗新生儿感染性肺炎的临床效果  

Analysis of the clinical effect of ambroxol hydrochloride combined with dopamine in the treatment of neonatal infectious pneumonia

作　　者：左蜀媛 李梓齐 ZUO Shu-yuan;LI Zi-qi(Zhoucun District People's Hospital,Zibo 255300,China)

机构地区：[1]山东省淄博市周村区人民医院,255300

出　　处：《中国实用医药》2024年第4期108-111,共4页China Practical Medicine

摘　　要：目的试析新生儿感染性肺炎采用多巴胺、盐酸氨溴索联合治疗的实际效果。方法在儿科收治的感染性肺炎新生儿中选择80例进行观察,经随机数表法分为对照组及观察组,每组40例。对照组予以常规治疗,观察组在常规治疗基础上予以盐酸氨溴索+多巴胺治疗。对比两组新生儿治疗后肺啰音消失时间、喘息缓解时间、咳嗽缓解时间、呼吸困难消失时间,临床疗效,治疗前后血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))],不良反应发生情况。结果观察组患儿的肺啰音消失时间、喘息缓解时间、咳嗽缓解时间、呼吸困难消失时间分别为(4.16±0.18)、(3.14±1.08)、(5.18±1.62)、(2.05±0.12)d,均短于对照组的(6.26±0.84)、(5.33±1.24)、(7.19±1.41)、(3.28±0.36)d,差异显著(P<0.05)。观察组总有效率为95.0%,高于对照组的77.5%,差异显著(P<0.05)。治疗后,两组患儿的PaO_(2)高于本组治疗前、PaCO_(2)低于本组治疗前,且观察组患儿的PaO_(2)(96.85±2.47)mm Hg(1 mm Hg=0.133 kPa)高于对照组的(81.83±2.47)mm Hg、PaCO_(2)(32.37±2.82)mm Hg低于对照组的(43.36±2.42)mm Hg,差异显著(P<0.05)。观察组不良反应发生率7.5%低于对照组的15.0%,但比较无差异(P>0.05)。结论新生儿感染性肺炎患儿接受盐酸氨溴索+多巴胺联合治疗后不良症状在短时间内消退,提升临床疗效的同时对新生儿血气指标调节效果理想,且药物安全性较高,不良反应较少,是值得积极应用的治疗方案。Objective To analyze the practical effect of ambroxol hydrochloride combined with dopamine in the treatment of neonatal infectious pneumonia.Methods 80 neonates with infectious pneumonia were selected for observation.They were divided by random number table into a control group and an observation group,each with 40 cases.The control group received symptomatic treatment,and the observation group received ambroxol hydrochloride+dopamine treatment.Comparison was made on disappearance time of pulmonary rale,the relief time of wheezing,the relief time of cough and the disappearance time of dyspnea after treatment,the clinical efficacy,the blood gas indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))]before and after treatment,and the occurrence of adverse reactions between the two groups.Results In the observation group,the disappearance time of pulmonary rale,the relief time of wheezing,the relief time of cough and the disappearance time of dyspnea were(4.16±0.18),(3.14±1.08),(5.18±1.62)and(2.05±0.12)d,which were shorter than(6.26±0.84),(5.33±1.24),(7.19±1.41)and(3.28±0.36)d in the control group,and the difference was significant(P<0.05).The total effective rate of the observation group was 95.0%,which was significantly higher than 77.5%of the control group(P<0.05).After treatment,PaO_(2)in both groups was higher than that before treatment,and PaCO_(2)was lower than that before treatment;the observation group had higher PaO_(2)of(96.85±2.47)mm Hg(1 mm Hg=0.133 kPa)than(81.83±2.47)mm Hg in the control group,and lower PaCO_(2)of(32.37±2.82)mm Hg than(43.36±2.42)mm Hg in the control group.The difference was significant(P<0.05).The incidence of adverse reactions in the observation group was 7.5%,which was lower than 15.0%in the control group,but there was no difference(P>0.05).Conclusion After ambroxol hydrochloride+dopamine combined treatment for neonates with infectious pneumonia,adverse symptoms will subside in a short time.It can improve clinical effi

关 键 词：新生儿 感染性肺炎 盐酸氨溴索 多巴胺 血气指标 

分 类 号：R722.135[医药卫生—儿科]