甲硝维参栓剂治疗细菌性阴道炎的效果研究  

Study on the effect of compound metronidazole suppository in the treatment of bacterial vaginitis

作　　者：李涛 朱敏 霍希霖 LI Tao;ZHU Min;HUO Xi-lin(Lanzhou First People's Hospital,Lanzhou 730050,China)

机构地区：[1]兰州市第一人民医院,730050 [2]甘肃医学院附属第一医院,744000 [3]天水市第一人民医院,741000

出　　处：《中国实用医药》2024年第4期122-125,共4页China Practical Medicine

摘　　要：目的探讨甲硝维参栓剂治疗细菌性阴道炎的临床疗效与安全性。方法360例符合入选标准的细菌性阴道炎患者,采用随机数字表法分为对照组A、对照组B及试验组,每组120例。对照组A给予甲硝唑栓治疗,对照组B给予甲硝唑阴道泡腾片治疗,试验组给予甲硝维参栓剂治疗。对比三组转阴率、阴道清洁度、治疗前后的白日瘙痒评分、复发情况、不良反应发生情况、药物依从性。结果试验组转阴率为85.00%,对照组A转阴率为67.50%,对照组B转阴率为70.83%;试验组转阴率高于对照组A与对照组B,差异有统计学意义(P<0.05)。治疗后,试验组阴道清洁度Ⅰ度占比76.67%高于对照组A的47.50%及对照组B的51.67%,Ⅱ度占比18.33%、Ⅲ度占比5.00%显著低于对照组A的30.00%、22.50%及对照组B的30.83%、17.50%,差异有统计学意义(P<0.05)。治疗后,三组白日瘙痒评分均低于本组治疗前,且试验组的白日瘙痒评分(0.87±0.21)分低于对照组A的(2.26±0.27)分和对照组B的(2.14±0.37)分,差异有统计学意义(P<0.05)。试验组复发率为3.33%,显著低于对照组A的14.17%和对照组B的10.83%,差异有统计学意义(P<0.05)。试验组患者不良反应发生率为1.67%,显著低于对照组A的13.33%和对照组B的10.00%,差异有统计学意义(P<0.05)。试验组药物总依从率为97.50%,高于对照组A的82.50%与对照组B的85.83%,差异有统计学意义(P<0.05)。结论甲硝维参栓剂治疗细菌性阴道炎可显著提高转阴率、改善白日瘙痒症状与阴道清洁度,并降低复发率和不良反应发生率,且患者依从性优于甲硝唑栓及甲硝唑阴道泡腾片治疗。Objective To explore the clinical efficacy and safety of compound metronidazole suppository in the treatment of bacterial vaginitis.Methods A total of 360 patients with bacterial vaginitis who met the inclusion criteria were divided into control group A,control group B and experimental group by random number table method,with 120 cases in each group.The control group A was treated with metronidazole suppository,the control group B was treated with metronidazole vaginal effervescent tablet,and the experimental group was treated with compound metronidazole suppository.The rate of negative conversion,vaginal cleanliness,daytime pruritus score before and after treatment,recurrence,adverse reactions,and drug compliance were compared among the three groups.Results The rate of negative conversion of the experimental group was 85.00%,that of the control group A was 67.50%,and that of the control group B was 70.83%.The rate of negative conversion in the experimental group was higher than that in control group A and control group B,and the difference was statistically significant(P<0.05).After treatment,the proportion ofⅠdegree of vaginal cleanliness in the experimental group was 76.67%,which was higher than 47.50%in the control group A and 51.67%in the control group B;the proportion ofⅡandⅢdegree of vaginal cleanliness were 18.33%and 5.00%,which were significantly lower than 30.00%and 22.50%in the control group A and 30.83%and 17.50%in the control group B;the difference was statistically significant(P<0.05).After treatment,the daytime itch score of all groups was lower than that before treatment;the daytime pruritus score was(0.87±0.21)points in the experimental group,which was lower than(2.26±0.27)points in the control group A and(2.14±0.37)points in the control group B;the difference was statistically significant(P<0.05).The recurrence rate of the experimental group was 3.33%,which was significantly lower than 14.17%of the control group A and 10.83%of the control group B,and the difference was statistically sig

关 键 词：甲硝维参栓剂 细菌性阴道炎 甲硝唑栓 甲硝唑阴道泡腾片 

分 类 号：R711.31[医药卫生—妇产科学]