黄芪桂枝五物汤加减治疗肿瘤化疗相关末梢神经炎的效果观察  

Observation on the effect of modified Huangqi Guizhi Wuwu decoction on chemotherapy related peripheral neuritis

作　　者：王双双 WANG Shuang-shuang(Department of Traditional Chinese Medicine,Suining County Traditional Chinese Medicine Hospital,Xuzhou 221200,China)

机构地区：[1]江苏省徐州市睢宁县中医院中医内科,221200

出　　处：《中国实用医药》2024年第4期153-156,共4页China Practical Medicine

摘　　要：目的分析黄芪桂枝五物汤加减治疗肿瘤化疗相关末梢神经炎的临床效果。方法100例肿瘤化疗相关末梢神经炎患者,按随机数字表法分成对照组与观察组,每组50例。对照组患者采取常规西医治疗,观察组患者采取黄芪桂枝五物汤加减治疗。对比两组患者中医临床证候积分(SLEFI)和疗效。结果治疗前,两组倦怠乏力、下肢麻木、四肢疼痛积分对比,差异无统计学意义(P>0.05);治疗后,观察组倦怠乏力、下肢麻木、四肢疼痛积分分别为(0.76±0.17)、(0.68±0.25)、(0.76±0.21)分,低于对照组的(1.57±0.26)、(1.82±0.37)、(1.75±0.24)分,差异有统计学意义(P<0.05)。观察组患者治疗总有效率96.00%(48/50)高于对照组的70.00%(35/50),差异有统计学意义(χ^(2)=11.977,P<0.05)。结论黄芪桂枝五物汤加减治疗肿瘤化疗相关末梢神经炎能够减轻患者的症状,效果优于西药治疗。Objective To analyze the clinical effect of modified Huangqi Guizhi Wuwu decoction on chemotherapy related peripheral neuritis.Methods 100 patients with tumor chemotherapy-related peripheral neuritis were divided into a control group and an observation group according to the random number method,with 50 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with modified Huangqi Guizhi Wuwu Decoction.The TCM clinical syndrome score(SLEFI)and curative effect were compared between the two groups.Results Before treatment,there was no significant difference in scores of burnout,fatigue,lower limb numbness and limb pain between the two groups(P>0.05).After treatment,the scores of burnout,fatigue,lower limb numbness and limb pain were(0.76±0.17),(0.68±0.25)and(0.76±0.21)points,which were lower than(1.57±0.26),(1.82±0.37)and(1.75±0.24)points in the control group.The difference was statistically significant(P<0.05).The total effective rate of the observation group was 96.00%(48/50),which was higher than 70.00%(35/50)of the control group,and the difference was statistically significant(χ^(2)=11.977,P<0.05).Conclusion Modified Huangqi Guizhi Wuwu decoction can reduce the symptoms of patients with tumor chemotherapy-related peripheral neuritis,and the effect is better than that of Western medicine treatment.

关 键 词：黄芪桂枝五物汤 末梢神经炎 化疗 治疗效果 

分 类 号：R273[医药卫生—中西医结合]