小剂量纳洛酮对患者阿片类药物术后镇痛时恶心呕吐发生的影响:meta分析  

Effect of small-dose naloxone on development of nausea and vomiting during postoperative analgesia with opioid drugs:a meta-analysis

作　　者：杨旭 王晓冬[1] 王彩霞[1] 丁玉美[1] 邱颐[1] Yang Xu;Wang Xiaodong;Wang Caixia;Ding Yumei;Qiu Yi(Department of Anesthesia Surgery Center,the Second Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010030,China)

机构地区：[1]内蒙古医科大学第二附属医院麻醉手术中心,呼和浩特010030

出　　处：《中华麻醉学杂志》2023年第12期1459-1464,共6页Chinese Journal of Anesthesiology

基　　金：2021年内蒙古医科大学重点项目(YKD2021ZD010);2022年内蒙古医科大学科技创新团队(YKD2022TD032)。

摘　　要：目的采用meta分析评价小剂量纳洛酮对患者阿片类药物术后镇痛时恶心呕吐发生的影响。方法计算机检索Pubmed、Embase、Cochrane、Web of Science、中国知网、万方医学网、中国生物医学文献服务系统和维普资讯,查找小剂量纳洛酮对阿片类药物术后镇痛时不良反应发生影响的随机对照研究,检索时限为建库至2023年5月。纳入的随机对照研究均包含纳洛酮组和对照组,主要评价指标为术后恶心呕吐发生率,次要评价指标为术后VAS评分。采用Stata 16.0软件进行meta分析。结果纳入7篇文献,共计542例患者。与对照组相比,纳洛酮组阿片类药物术后镇痛时恶心呕吐发生率降低(P<0.05),术后VAS评分差异无统计学意义(P>0.05)。结论小剂量纳洛酮可减少患者阿片类药物术后镇痛时恶心呕吐的发生。Objective To systematically review and evaluate the effect of small-dose naloxone on the development of nausea and vomiting during postoperative analgesia with opioid drugs in patients.Methods Electronic Databases including Pubmed,Embase,Cochrane,Web of Science,China National Knowledge Infrastructure,Wanfang Data,China Biomedical Literature Database,and China Science and Technology Journal Database databases were searched from inception to May 2023 for randomized controlled trials involving the effect of small-dose naloxone on the development of adverse effects during postoperative analgesia with opioids.All randomized controlled trials enrolled included naloxone group and control group,the primary outcome was the incidence of postoperative nausea and vomiting,and the secondary outcome was postoperative VAS.Meta-analysis was performed using Stata 16.0 software.Results Seven randomized controlled trials involving 542 patients were finally included in this meta-analysis.Compared with control group,the incidence of nausea and vomiting during postoperative analgesia was significantly decreased in naloxone group(P<0.05),and no significant change was found in postoperative VAS scores(P>0.05).Conclusions Small-dose naloxone can reduce the development of nausea and vomiting during postoperative analgesia with opioid drugs.

关 键 词：纳洛酮 镇痛药 阿片类 镇痛 手术后恶心呕吐 META分析 

分 类 号：R614[医药卫生—麻醉学]