基因位点检测在老年常见复杂疾病风险评估及个体化干预中的应用  

Application of gene locus detection for risk assessment and individualized intervention of common complex diseases in the elderly

作　　者：和昱辰 刘家云 He Yunchen;Liu Jiayun(Department of Clinical Laboratory,Xijing Hospital,Airforce Military Medical University,Xi'an 710032,Shannxi,China)

机构地区：[1]空军军医大学第一附属西京医院检验科,陕西西安710032

出　　处：《中国医学前沿杂志（电子版）》2024年第1期84-91,共8页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：在步入老龄化社会的今天,早期筛查和诊断老年人常见的复杂疾病变得愈发重要。因此,本文旨在总结临床上与老年常见复杂疾病相关的几种常见基因位点检测项目,例如血栓高危风险评估、脑卒中风险评估、痴呆风险评估和2型糖尿病风险评估,并以氯吡格雷、阿司匹林、华法林及二甲双胍为例,针对不同基因型提出了个体化用药方案及相应的用药建议。最后,我们还列举了常见的个体化用药基因位点检测方法。通过本文的介绍,希望能为老年常见复杂疾病的早期发现和个体化干预提供参考依据。Wtih a rapidly increase of aging population,early detection and diagnosis of common age-related complex diseases become more important.As such,this review aims to comprehensively summarize several gene loci testing projects that are commonly utilized in clinical settings for assessing high-risk thrombosis,stroke,dementia,and type 2 diabetes in elderly patients.Furthermore,we propose individualized medication plans and corresponding drug recommendations based upon diverse genotypes,taking clopidogrel aspirin,walfarin and metformin as examples.Ultimately,this article is helpful to provide references and tools to effectively screen,treat,and manage elderly patients with complex diseases.

关 键 词：老年人 常见复杂疾病 基因位点检测 疾病风险评估 个体化干预 

分 类 号：R440[医药卫生—诊断学]