顶复门原虫多胺合成研究进展  

Advance in Polyamine Synthesis of Apicomplexan Parasites

作　　者：殷熙娟 廖申权 戚南山 李娟 吕敏娜 蔡海明 胡俊菁 林栩慧 宋勇乐 张健騑 刘文俊[1] 孙铭飞 YIN Xi-juan;LIAO Shen-quan;QI Nan-shan;LI Juan;L Min-na;CAI Hai-ming;HU Jun-jing;LIN Xu-hui;SONG Yong-le;ZHANG Jian-fei;LIU Wen-jun;SUN Ming-fei(Zhongkai University of Agriculture and Engineering,Guangzhou,510225,China;Institute of Animal Health,Guangdong Academy of Agricultural Sciences,Key Laboratory of Avian Influenza and Other Major Poultry Diseases Prevention and Control,Key Laboratory of Livestock Disease Prevention of Guangdong Province,Maoming Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology,Guangzhou,510640,China)

机构地区：[1]仲恺农业工程学院,广东广州510225 [2]广东省农业科学院动物卫生研究所,农业农村部禽流感等家禽重大疫病防控重点实验室,广东省畜禽疫病防治研究重点实验室,岭南现代农业科学与技术广东省实验室茂名分中心,广东广州510640

出　　处：《动物医学进展》2024年第2期105-110,共6页Progress In Veterinary Medicine

基　　金：广东省农业科学院科技创新战略专项基金(XTXM202202,202122TD,R2020PY-JC001,R2020PY-JG013);广东省重点领域研究计划项目(2020B0202080004);广东省基础与应用基础研究基金项目(2021A1515012401,2021A1515010521);广东省现代农业产业技术体系创新团队建设专项资金(2023KJ119)。

摘　　要：多胺是一类聚阳离子脂肪族化合物,广泛存在于生物体内,其在顶复门原虫的生长、发育和繁殖等多个阶段发挥着重要作用。顶复门原虫的多胺合成途径存在多样性,其与宿主细胞的经典路径不同,且顶复门原虫多胺生物合成限速酶(鸟氨酸脱羧酶与S-腺苷甲硫氨酸脱羧酶)的半衰期与宿主细胞限速酶的半衰期存在显著差异。因此,顶复门原虫多胺合成限速酶及转运载体成为抗原虫药物研发的候选靶标,以顶复门原虫多胺合成限速酶及多胺转运载体为靶标的抗寄生原虫抑制剂研究取得一定进展。论文综述了顶复门原虫多胺的生物学功能、生物合成途径及其抑制剂研究进展,以期为抗原虫药物靶标研究及新型抑制剂研发提供参考。Polyamines are positively-charged organic molecules that have two or more primary amino groups.These molecules occur in all eukaryotic cells and play important roles in the parasite survival,growth and proliferation.In eukaryotes,polyamine synthesis typically starts with ornithine,while,polyamine metabolism is highly divergent among apicomplexans.Furthermore,the rate-limiting enzymes of mammalian polyamine synthesis,such as ornithine decarboxylase(ODC)and S-adenosylmethionine decarboxylase(AdoMetDC)have extremely short half-lives whereas parasite ODC and AdoMetDC have half-life of more than 2 h.Therefore,enzymes in polyamine synthesis and transporters of polyamine are considered as potential targets of antiparasitic therapies.In this review,the biological function and biosynthesis of polyamines,and inhibitor discovery of polyamine synthesis and transport in apicomplexan parasites were reviewed,in order to provide references for the development of therapeutic agents for the treatment of diseases caused by apicomplexan parasites.

关 键 词：顶复门原虫 多胺合成 药物靶标 

分 类 号：S852.7[农业科学—基础兽医学]