血清GM-CSF、IGF-1联合检测在妊娠期糖尿病患者不良妊娠结局诊断中的价值  

Value of combined detection of serum GM-CSF and IGF-1 levels in diagnosis of adverse pregnancy outcomes in patients with gestational diabetes mellitus

作　　者：孙言非 SUN Yanfei(Department of Clinical Laboratory of the Central Hospital of Jiamusi City,Jiamusi 154002 Heilongjiang,China)

机构地区：[1]佳木斯市中心医院检验科,黑龙江佳木斯154002

出　　处：《中国民康医学》2024年第3期132-134,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清粒细胞-巨噬细胞集落刺激因子(GM-CSF)、胰岛素样生长因子-1(IGF-1)联合检测在妊娠期糖尿病(GDM)患者不良妊娠结局诊断中的价值。方法:选取2021年6月至2023年3月该院收治的83例GDM患者设为研究组,根据妊娠结局将其分为不良结局患者(n=24)和良好结局患者(n=59),另选取同期160名健康孕妇作为对照组,比较两组及不同妊娠结局GDM患者血清GM-CSF、IGF-1水平,绘制受试者工作特征(ROC)曲线,分析血清GM-CSF、IGF-1单项及联合检测在GDM患者不良妊娠结局诊断中的价值。结果:研究组血清IGF-1水平低于对照组,GM-CSF水平高于对照组,差异均有统计学意义(P<0.05);不良结局患者IGF-1水平低于良好结局患者,GM-CSF水平高于良好结局患者,差异均有统计学意义(P<0.05);ROC曲线分析结果显示,血清IGF-1、GM-CSF单项及联合检测诊断GDM患者不良妊娠结局的曲线下面积分别为0.821、0.822、0.912,均具有一定诊断价值,且联合检测诊断价值最高。结论:血清GM-CSF、IGF-1联合检测在GDM患者不良娠结局诊断中的价值高于二者单项检测。Objective:To analyze value of combined detection of serum granulocyte macrophage-colony stimulating factor(GM-CSF)and insulin growth factor-1(IGF-1)levels in diagnosis of adverse pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods:A total of 83 patients with GDM admitted to this hospital from June 2021 to March 2023 were selected as the study group.According to the pregnancy outcome,they were divided into the patients with adverse outcomes(n=24)and the patients with good outcomes(n=59).Another 160 healthy pregnant women in the same period were selected as the control group.The levels of serum GM-CSF and IGF-1 in the two groups and the GDM patients with different pregnancy outcomes were compared.The receiver operating characteristic(ROC)curve was drawn to analyze the value of single and combined detection of serum GM-CSF and IGF-1 levels in the diagnosis of adverse pregnancy outcomes in the GDM patients.Results:The level of IGF-1 in the study group was lower than that in the control group,the level of GM-CSF was higher than that in the control group,and the differences were statistically significant(P<0.05).The level of IGF-1 in the patients with adverse outcomes was lower than that in the patients with good outcomes,the level of GM-CSF was higher than that in the patients with good outcomes,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the areas under the curve of single and combined detection of serum IGF-1 and GM-CSF levels in the diagnosis of adverse pregnancy outcomes in the GDM patients was 0.821,0.822 and 0.912,respectively,all of which had certain diagnostic value,and the combined detection had the highest diagnostic value.Conclusions:The value of combined detection of serum GM-CSF and IGF-1 levels in the diagnosis of adverse pregnancy outcomes in the GDM patients is higher than that of single detection.

关 键 词：妊娠糖尿病 粒细胞-巨噬细胞集落刺激因子 胰岛素样生长因子-1 妊娠结局 诊断 价值 

分 类 号：R714.25[医药卫生—妇产科学]