加味补肾生髓成肝方联合聚乙二醇干扰素α对慢性乙型肝炎患者肝纤维化的影响  

Effect of Jiawei Bushen Shengsui Chenggan Prescription Combined with Pegylated Interferon Alpha on Liver Fibrosis in Patients with Chronic Hepatitis B

作　　者：戎云清 徐敬轩[2] RONG Yunqing;XU Jingxuan(Department of Infectious Diseases,Danyang Second People's Hospital,Danyang,Jiangsu Province,212300 China;Department of Clinical Laboratory,Danyang Second People's Hospital,Danyang,Jiangsu Province,212300 China)

机构地区：[1]江苏省丹阳市第二人民医院感染病科,江苏丹阳212300 [2]江苏省丹阳市第二人民医院检验科,江苏丹阳212300

出　　处：《世界复合医学》2023年第12期98-102,共5页World Journal of Complex Medicine

摘　　要：目的分析加味补肾生髓成肝方联合聚乙二醇干扰素α对慢性乙型肝炎患者肝纤维化的影响。方法随机选取2022年1月—2023年1月江苏省丹阳市第二人民医院收治的80例慢性乙型肝炎患者为研究对象,按照不同的治疗方式分为对照组、观察组,各40例。给予对照组患者行聚乙二醇干扰素α,观察组在对照组基础上给予加味补肾生髓成肝方。对比两组患者肝纤维化[透明质酸(hyaluronic acid plum,HA)、Ⅳ型胶原(type-iv collagen,IV-C)、Ⅲ型前胶原(procollagenⅢ,PCⅢ)、层粘连蛋白(laminin,LN)]、血清细胞因子[白细胞介素-2(interleukin-2,IL-2)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-10(interleukin-10,IL-10)]、肝功能[谷丙转氨酶(alanine transaminase,ALT)、谷草转氨酶(glutamic oxalacetic transaminase,AST)]、乙肝病毒脱氧核糖核酸(hepatitis B virus DNA,HBV DNA)、乙肝病毒e抗原(hepatitis B virus e antigen,HBeAg)转阴率、总不良反应、总有效率。结果治疗前,两组患者HA、IV-C、PCⅢ、LN比较,差异无统计学意义(P均>0.05);治疗后,观察组患者HA、IVC、PCⅢ、LN水平均低于对照组,差异有统计学意义(P均<0.05)。观察组患者IL-2水平高于对照组,IL-6、IL-10低于对照组,差异有统计学意义(P均<0.05)。观察组患者ALT、AST水平显著低于对照组,差异有统计学意义(P均<0.05)。观察组患者HBV DNA、HBeAg转阴率分别为70.00%、80.00%显著高于对照组,差异有统计学意义(P均<0.05)。观察组不良反应总发生率为5.00%,低于对照组的20.00%,差异有统计学意义(P<0.05)。观察组的总有效率为97.50%,高于对照组的85.00,差异有统计学意义(P<0.05)。结论在慢性乙型肝炎患者治疗过程中,加味补肾生髓成肝方联合聚乙二醇干扰素α对患者的肝纤维化与肝功能有效改善,并且患者的总有效率较高,值得临床推广应用。Objective To analyze the effects of Jiawei Bushen Shengsui Chenggan prescription combined with pegylated interferon alpha on liver fibrosis in patients with chronic hepatitis B.Methods 80 patients with chronic hepatitis B admitted to the Second People's Hospital of Danyang City,Jiangsu Province from January 2022 to January 2023 were randomly selected as the research subjects.They were divided into a control group and an observation group according to different treatment methods,with 40 cases in each group.Control group was given polyethylene glycol interferonα,the observation group was given modified Jiawei Bushen Shengsui Chenggan Prescription on the basis of the control group.Compare two groups of patients with liver fibrosis[hyaluronic acid plum(HA),type IV collagen(IV-C),type III procollagen(PC III),laminin(LN)],serum cytokines[interleukin-2(IL-2),interleukin-6(IL-6),and interleukin-10(IL-10)]Liver function[alanine transaminase(ALT),glutamic oxaloacetic transaminase(AST)],hepatitis B B virus DNA(HBV DNA),hepatitis B B virus e antigen(HBeAg)negative conversion rate,total adverse reactions,and total effective rate.Results Before treatment,there was no statistically significant difference in HA,IV-C,PC III,and LN between the two groups of patients(all P>0.05);After treatment,the levels of HA,IV-C,PC III,and LN in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The levels of IL-2 in the observation group were higher than those in the control group,while IL-6 and IL-10 were lower than those in the control group,and the differences were statistically significant(all P<0.05).The levels of ALT and AST in the observation group were significantly lower than those in the control group,and the differences were statistically significant(all P<0.05).The HBV DNA and HBeAg conversion rates in the observation group were 70.00%and 80.00%,respectively,significantly higher than those in the control group,and the differences were statistically signif

关 键 词：加味补肾生髓成肝方 聚乙二醇干扰素Α 慢性乙型肝炎 肝纤维化 

分 类 号：R4[医药卫生—临床医学]