中西医结合治疗终末期肾病患者的疗效分析  

Effect of Integrated Chinese and Western Medicine on Patients with End-stage Renal Disease

作　　者：裴海丽 薛国忠 张桂凤 PEI Haili;XUE Guozhong;ZHANG Guifeng(Department of Integrated Traditional Chinese and Western Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu Province,730000 China;Department of Blood Purification Room,Wushan County People's Hospital,Wushan,Gansu Province,741300 China;Department of Blood Purification Center,the Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu Province,730000 China;Department of Internal Medicine II,Wushan County People's Hospital,Wushan,Gansu Province,741300 China)

机构地区：[1]甘肃中医药大学中西医结合系,甘肃兰州730000 [2]武山县人民医院血液净化室,甘肃武山741300 [3]甘肃中医药大学附属医院血液净化中心,甘肃兰州730000 [4]武山县人民医院内二科,甘肃武山741300

出　　处：《世界复合医学》2023年第12期143-145,149,共4页World Journal of Complex Medicine

摘　　要：目的探讨对终末期肾病患者给予中西医结合治疗后获得临床效果。方法便利选取2020年2月—2023年5月甘肃中医药大学/武山县人民医院收治的68例终末期肾病患者为研究对象,依据投掷硬币法分为两组。参照组(34例)采用血液透析治疗方法,研究组(34例)在参照组基础上添加甘草干姜汤治疗;比较两组患者的治疗总有效率、尿素氮(blood urea nitrogen,BUN)水平、血肌酐(serum creatinine,Scr)水平、甲状腺旁腺素(parathyroid hormone,PTH)水平、血清β2微球蛋白(β2-microglobulin,β2-MG)水平、中医证候积分。结果与参照组治疗总有效率(76.47%)比较,研究组患者治疗总有效率(97.06%)更高,差异有统计学意义(χ^(2)=6.275,P<0.05);治疗后,与参照组BUN、Scr水平比较,研究组更低,差异有统计学意义(P均<0.05);治疗后,与参照组PTH、β2-MG水平比较,研究组更低,差异有统计学意义(P均<0.05);与参照组中医证候积分比较,研究组更低,差异有统计学意义(P<0.05)。结论临床对终末期肾病患者在治疗期间,中西医结合疗法的有效应用,可将患者的疗效显著提升,将系列指标显著改善,将中医证候积分显著降低。Objective To explore the clinical effect of integrated Chinese and western medicine in patients with end-stage renal disease.Methods A total of 68 patients with end-stage renal disease admitted to Gansu University of Traditional Chinese Medicine/Wushan County People's Hospital from February 2020 to May 2023 were conveniently selected as the research objects and divided into two groups according to the coin toss method.The reference group(34 cases)was treated with hemodialysis,and the study group(34 cases)was treated with Gancao Ginger Decoction on the basis of the reference group.The total effective rate,blood urea nitrogen(BUN)level,serum creatinine(Scr)level,parathyroid hormone(PTH)level,serumβ2-microglobulin(β2-MG)level and TCM syndrome score of two groups of patients with end-stage renal disease were compared.Results Compared with the total effective rate(76.47%)of the reference group,the total effective rate(97.06%)of the study group was higher,and the difference was statistically significant(χ^(2)=6.275,P<0.05).After treatment,compared with the BUN and Scr levels of the reference group,the study group was lower,and the differences were statistically significant(both P<0.05).After treatment,the levels of PTH andβ2-MG in the study group were lower than those in the reference group,and the differences were statistically significant(both P<0.05).Compared with the TCM syndrome score of the reference group,the study group was lower,and the difference was statistically significant(P<0.05).Conclusion During the treatment of patients with end-stage renal disease,the effective application of integrated Chinese and western medicine therapy can significantly improve the efficacy of patients,significantly improve the series of indicators,and significantly reduce the TCM syndrome score.

关 键 词：中西医结合 终末期肾病 疗效 尿素氨水平 血肌酐水平 甲状腺旁腺素水平 血清β2微球蛋白水平 中医证候积分 

分 类 号：R692[医药卫生—泌尿科学]