基于肠道菌群探讨补肾益精法治疗少弱精子症的作用机制  

Mechanism of Bushen Yijing Method in Treatment of Oligoasthenozoospermia Based on Intestinal Microbiota

作　　者：黄念文 李海松[1] 毕焕洲 王彬[1] 冯隽龙 孙龙吉 王继升[1] 王成李[3] HUANG Nianwen;LI Haisong;BI Huanzhou;WANG Bin;FENG Juanlong;SUN Longji;WANG Jisheng;WANG Chengli(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Shenzhen Hospital,Beijing University of Chinese Medicine,Shenzhen 518172,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学深圳医院,广州深圳518172 [3]北京中医药大学东方医院,北京100078

出　　处：《中国实验方剂学杂志》2024年第5期170-175,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81973845);中华中医药学会青年求实项目(2021-QNQS-03)。

摘　　要：少弱精子症是引起男性不育的主要原因,其病因复杂多样,目前临床上仍有部分少弱精子症的病因未明,称为特发性少弱精子症。随着高通量测序技术的发展,发现肠道菌群紊乱可能是少弱精子症发病的一个重要促进因素。中医学认为“肾精亏虚”为少弱精子症的核心病机,临床上采用补肾益精法治疗少弱精子症疗效显著,但其作用机制尚未完全阐明。结合中医基础理论及分子生物学研究发现,“肾精”与肠道菌群具有相似性,在少弱精子症发病过程中,肠道菌群紊乱与中医“肾精亏虚”病机有共通之处,且补肾益精类中药可调节肠道菌群紊乱,这或许是补肾益精法有效治疗少弱精子症的机制之一。基于此,该文从肠道菌群角度探讨中医补肾益精法治疗少弱精子症的作用机制,以期为中医药治疗少弱精子症提供新的思路。Oligoasthenozoospermia is the main cause of male infertility,with complex and diverse causes.Currently,there are still some unclear causes of oligoasthenozoospermia in clinical practice,known as idiopathic oligoasthenozoospermia.With the development of high-throughput sequencing technology,it has been found that intestinal microbiota disorder may be an important promoting factor for the onset of oligoasthenozoospermia.Traditional Chinese medicine believes that"deficiency of kidney essence"is the core pathogenesis of oligoasthenozoospermia.In clinical practice,the method of tonifying the kidney and strengthening the essence has a significant therapeutic effect on oligoasthenozoospermia,but its mechanism of action has not been fully elucidated.Based on the basic theories of traditional Chinese medicine and molecular biology research,it has been found that there is a similarity between"kidney essence"and intestinal microbiota.During the onset of oligoasthenozoospermia,the disorder of intestinal microbiota has similarities with the pathogenesis of"deficiency of kidney essence"in traditional Chinese medicine.Moreover,traditional Chinese medicine for tonifying the kidney and strengthening the essence can regulate the disorder of intestinal microbiota,which may be one of the effective mechanisms for the treatment of oligoasthenozoospermia with the Bushen Yijing method.Based on this,this article explored the mechanism of Bushen Yijing method of traditional Chinese medicine in treating oligoasthenozoospermia from the perspective of intestinal microbiota,so as to provide new ideas for the treatment of oligoasthenozoospermia with traditional Chinese medicine.

关 键 词：少弱精子症 肠道菌群 肾精亏虚 补肾益精 中医中药 

分 类 号：R242[医药卫生—中医临床基础] R2-0[医药卫生—中医学] R2-031R256.56R699