益气化瘀解毒法联合化疗治疗晚期胃肠道恶性肿瘤的临床观察  

Clinical observation of the chemotherapy combined with the TCM therapy of replenishing Qi,resolving stasis and detoxification for the treatment of advanced gastrointestinal malignant tumors

作　　者：沈迪 郜妙 SHEN Di;GAO Miao(Department of Oncology,Yangzhou Jiangdu Hospital of Chinese Medicine,Yangzhou 225299,China)

机构地区：[1]扬州市江都中医院肿瘤科,扬州225299

出　　处：《上海医药》2024年第3期28-32,共5页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨益气化瘀解毒法联合化疗对晚期胃癌和肠癌患者的临床疗效和生活质量的影响。方法:将53例晚期胃癌和12例肠癌患者随机分为对照组(n=33)和观察组(n=32),对照组给以奥沙利铂+卡培他滨联合化疗方案,观察组在对照的基础上根据中医辨证的结果应用益气化瘀解毒法治疗,比较两组疗效。结果:治疗后,观察组中医证候积分、生命质量核心量表评分、肿瘤坏死因子-a水平、肿瘤标志物水平以及不良反应发生率均低于对照组;生活质量评分、白细胞计数高于对照组(P<0.05)。结论:益气化瘀解毒法联合化疗对胃肠道恶性肿瘤患者疗效确切,能改善患者的生活质量。Objective:To explore the clinical efficacy and quality of life of the chemotherapy combined with the traditional Chinese medicine(TCM)named replenishing Qi,resolving stasis and detoxification in the treatment of the patients with advanced gastric and intestinal cancers.Methods:Fifty-three patients with advanced gastric cancer and twelve patients with intestinal cancer were randomly divided into a control group(n=33)and an observation group(n=32).The control group was given an oxaliplatin+capecitabine combination chemotherapy program,and the observation group was treated with the TCM therapy of replenishing Qi,resolving stasis and detoxification according to the results of TCM identification based on the control group.The efficacy was compared between the two groups.Results:After treatment,the TCM evidence points,quality of life core scale scores,levels of tumor necrosis factor-a,levels of tumor markers,and the incidence of adverse reactions were lower,and the scores of quality of life and white blood cell count were higher in the observation group than the control group(all P<0.05).Conclusion:The TCM therapy of replenishing Qi,resolving stasis and detoxification combined with chemotherapy is effective in patients with gastrointestinal malignant tumors and can improve the quality of life of the patients.

关 键 词：益气化瘀解毒法 化疗 晚期胃癌 肠癌 生活质量 免疫功能 

分 类 号：R289.5[医药卫生—方剂学] R735[医药卫生—中药学]