血清25羟维生素D3与成纤维细胞生长因子23在社区2型糖尿病合并高血压患者中的变化研究  

Changes of serum 25 hydroxyvitamin D3 and fibroblast growth factor 23 in community type 2 diabetes patients with hypertension

作　　者：尹冰逸 黄冬娟 胡敏 Yin Bingyi;Huang Dongjuan;Hu Min(General Medicine Department,Community Health Service Center,Tianmu West Road,Jing′an District,Shanghai 200070,China)

机构地区：[1]上海市静安区天目西路社区卫生服务中心全科医学科,200070 [2]上海市静安区天目西路社区卫生服务中心心内科,200070

出　　处：《山西医药杂志》2024年第1期26-29,共4页Shanxi Medical Journal

摘　　要：目的分析社区2型糖尿病合并高血压与血清25羟基维生素D3[25-(OH)D3]与成纤维细胞生长因子23(FGF23)的相关性。方法检测和对比单纯糖尿病患者、单纯高血压患者、非糖尿病及非高血压体检者及糖尿病合并高血压患者25-(OH)D3及FGF23水平、血糖、血压及血脂水平并分析25-(OH)D3及FGF23与血糖、血压及血脂指标相关性。结果相比于对照组,单纯糖尿病组、单纯高血压组及糖尿病合并高血压组患者25-(OH)D3水平均更高,FGF23水平均更低(P<0.05)。与糖尿病合并高血压组相比,单纯糖尿病组及单纯高血压组25-(OH)D3水平均更高,FGF23水平均更低(P<0.05)。单纯糖尿病组25-(OH)D3水平低于单纯高血压组,FGF23水平高于单纯高血压组(P<0.05)。相比于对照组,单纯糖尿病组、单纯高血压组及糖尿病合并高血压组患者血糖、血压及血脂指标水平均更高(P<0.05)。与单纯糖尿病组及单纯高血压组相比,糖尿病合并高血压组血糖、血压及血脂指标水平均更高(P<0.05)。与单纯糖尿病组相比,单纯高血压组舒张压、收缩压、总胆固醇及甘油三酯水平均更高,空腹血糖、餐后2 h血糖、糖化血红蛋白水平均更低(P<0.05)。25-(OH)D3与血糖、血压及血脂指标水平呈负相关(P<0.05),FGF23与各项指标水平呈正相关(P<0.05)。结论社区2型糖尿病合并高血压与25-(OH)D3水平呈负相关,与FGF23水平呈正相关,临床可根据25-(OH)D3及FGF23水平采取干预措施以控制病情进展。Objective To analyze the correlation between type 2 diabetes with hypertension in the community and serum 25 hydroxyvitamin D3[25-(OH)D3]and fibroblast growth factor 23(FGF23).Methods The levels of 25-(OH)D3 and FGF23,blood glucose,blood pressure,and blood lipid in patients with simple diabetes,patients with simple hypertension,patients with non-diabetes and non-hypertension,and patients with diabetes combined with hypertension were detected and compared,and the correlation between 25-(OH)D3,FGF23 and blood glucose,blood pressure and blood lipid were analyzed.Results Compared with the control group,the levels of 25-(OH)D3 were lower in the simple diabetes group,the simple hypertension group and the diabetes with hypertension group,while the levels of FGF23 were higher(P<0.05).Compared with diabetes with hypertension group,the levels of 25-(OH)D3 and FGF23 in diabetes alone group and hypertension alone group were higher and lower(P<0.05).The level of 25-(OH)D3 in the simple diabetes group was lower than that in the simple hypertension group,and the level of FGF23 was higher than that in simple hypertension group(P<0.05).Compared with the control group,the blood glucose,blood pressure and blood lipid levels of patients with simple diabetes,simple hypertension and diabetes with hypertension were higher(P<0.05).Compared with the simple diabetes group and the simple hypertension group,the levels of blood sugar,blood pressure and blood lipid in the diabetes with hypertension group were higher(P<0.05).Compared with the simple diabetes group,the levels of diastolic blood pressure,systolic pressure,total cholesterol and triglyceride in the simple hypertension group were higher,and the levels of fasting plasma glucose,2-hour postprandial blood glucose and glycosylated hemoglobin were lower on average(P<0.05).25-(OH)D3 was negatively correlated with blood glucose,blood pressure,and lipid levels(P<0.05),while FGF23 was positively correlated with various indicator levels(P<0.05).Conclusion Hypertension associated with type 2

关 键 词：骨化二醇 成纤维细胞生长因子23 糖尿病 2型 高血压 血脂 相关性 

分 类 号：R587.2[医药卫生—内分泌] R544.1[医药卫生—内科学]