环烯醚萜类化合物防治骨质疏松症作用机制的研究进展  

Research progress of mechanism of iridoids on prevention and treatment of osteoporosis

作　　者：梁晓霞 谢保城 罗世英 LIANG Xiaoxia;XIE Baocheng;LUO Shiying(School of Pharmacy,Guangdong Medical University,Zhanjiang 524023,China;Department of Pharmacy,Dongguan People's Hospital,Dongguan 523059,China)

机构地区：[1]广东医科大学药学院,广东湛江524023 [2]东莞市人民医院药学部,广东东莞523059

出　　处：《现代药物与临床》2024年第1期251-256,共6页Drugs & Clinic

基　　金：国家自然科学基金青年科学基金项目(82000842)。

摘　　要：骨质疏松已是全球健康问题,因此寻找安全、有效、不良反应少的抗骨质疏松症药物是社会所关注的问题。环烯醚萜类化合物在植物界分布较广,具有多种药理活性。环烯醚萜类化合物可通过多种途径促进成骨功能、抑制破骨功能,发挥抗骨质疏松作用。归纳了环烯醚萜类化合物抗骨质疏松症的作用机制,为开发新型抗骨疏松症药物提供参考。Osteoporosis is a global health issue,and finding safe,effective,and low adverse reaction anti-osteoporosis drugs is a social concern.Iridoids are widely available in various plants,and have multiple pharmacological effects.Iridoids can promote osteogenic function,inhibit osteoclast function,and exert anti-osteoporosis effects through various pathways.This article summarizes the mechanism of action of iridoids against osteoporosis,providing reference for the development of new anti-osteoporosis drugs.

关 键 词：环烯醚萜 骨质疏松症 成骨功能 破骨功能 作用机制 

分 类 号：R983[医药卫生—药品]