不同蓝光照射频率在新生儿高胆红素血症的应用效果  

Application effects of different blue light irradiation frequencies on neonatal hyperbilirubinemia

作　　者：关梦洁 刘雨露[1] Guan Meng-jie;Liu Yu-lu(NICU,Shangqiu First People’s Hospital,Shangqiu 471000,Henan,China)

机构地区：[1]商丘市第一人民医院新生儿重症监护室,河南商丘471000

出　　处：《四川生理科学杂志》2024年第2期273-275,共3页Sichuan Journal of Physiological Sciences

基　　金：国家卫生健康委“十四五”规划全国重点课题:枸橼酸咖啡因治疗新生儿呼吸暂停的研究(编号:YYWS2745)。

摘　　要：目的:研究不同蓝光照射频率治疗新生儿高胆红素血症(高胆)的疗效。方法:研究对象为2019年12至2022年2月本院收治的高胆患儿126例,按照随机单双号法分为对照组(63例)和观察组(63例)。两组患儿均接受常规药物治疗,再此基础上对照组患儿给予蓝光长时间照射,观察组则采用蓝光间歇照射。观察比较两组患儿治疗前和治疗第5 d的血清间接胆红素(Serum indirect bilirubin,IBiL)、血清总胆红素(Serum total bilirubin,TBiL)水平,及血清中血胱抑素C(Cystatin C,CysC)、α-谷胱甘肽-S转移酶(Glutathione S transferases-α,α-GST)、谷氨酸脱氢酶(Glutamic dehydrogenase,GLDH)三项水平及观察期间发生的不良反应发生情况。结果:两组患儿经不同蓝光照射频率治疗5 d后,患儿血清中IBiL、TBiL、CysC、α-GST及GLDH水平较治疗前均有显著下降(P<0.05),且观察组上述各项指标明显低于对照组(P<0.05);治疗期间,观察组患儿总不良反应发生率为11.11%,明显低于对照组的26.98%,差异比较具有统计学意义(P<0.05)。结论:采用蓝光间歇照射法治疗新生儿高胆红素血症,有明显疗效,且能显著降低新生儿血清胆红素水平及血清中各酶系水平,降低不良反应发生风险,更值得临床使用。Objective:To compare the efficacy of different blue light irradiation frequencies in the treatment of neonatal hyperbilirubinemia.Methods:126 children with hyperbilirubinemia who were treated in the hospital between December 2019 and February 2022 were enrolled as the research subjects,and they were divided into the control group(n=63)and the observation group(n=63)according to the random odd-even number method.Both groups of children received conventional drug treatment,and the control group was given long-term blue light irradiation based on conventional drug therapy,and the observation group received intermittent blue light irradiation based on conventional drug therapy.The jaundice subsidence time,hospital stay,meconium emptying time and stool frequency were compared between the two groups,and the levels of serum bilirubins[indirect bilirubin(IBiL),total bilirubin(TBiL)]and serum biochemical-related indicators[Cystatin C(CysC),α-glutathione-S transferase(α-GST),glutamate dehydrogenase(GLDH)]of the two groups were compared before treatment and on the 5th d of treatment,and the adverse reactions of the two groups were compared.Results:The jaundice subsidence time,hospital stay,meconium emptying time and stool frequency in the observation group were shorter or less than those in the control group(P<0.05).On the 5th d of light treatment,the levels of serum IBiL and TBiL in the two groups were significantly decreased(P<0.05),and the levels were significantly lower in the observation group than those in the control group(P<0.05).Serum levels of CysC,α-GST and GLDH in the two groups were significantly reduced on the 5th d of light treatment(P<0.05),and the above indicators in the observation group were significantly lower than those in the control group(P<0.05).During treatment,the total adverse reaction rate in the observation group was 11.11%,which was significantly lower than 26.98%in the control group(P<0.05).Conclusion:Intermittent blue light irradiation in the treatment of neonatal hyperbilirubinemia can si

关 键 词：蓝光间歇照射 蓝光长时间照射 新生儿高胆红素血症 胆红素 

分 类 号：R722.1[医药卫生—儿科]