探讨替加环素辅助头孢哌酮舒巴坦钠治疗严重腹腔感染的疗效  

Efficacy of tigacycline assisted cefoperazone-sulbactam sodium in the treatment of severe abdominal infection

作　　者：王向蒙 冯阳 安亚航 Wang Xiang-meng;Feng Yang;An Ya-hang(Department of Intensive Care Medicine,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan,China)

机构地区：[1]河南科技大学第一附属医院重症医学科,河南洛阳471000

出　　处：《四川生理科学杂志》2024年第2期294-296,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:替加环素辅助头孢哌酮舒巴坦钠治疗严重腹腔感染患者的效果以及炎症因子水平变化以及安全性。方法:选取我科2020年1月至2022年10月期间接收的80例严重腹腔感染患者作为研究对象,根据抽签法分为对照组和观察组两组。对照组(n=40)实施头孢哌酮舒巴坦钠治疗,观察组(n=40)在此基础上增加替加环素治疗,治疗两周后采用酶联免疫吸附法检测白介素-6(Interleukin-6,IL-6)水平,采用免疫层析法检测C-反应蛋白(Creactionprotein,CRP)、降钙素原(Procalcitonin,PCT)等,对比两组患者炎性因子水平;采用急性生理与慢性健康状况评分Ⅱ(Acute physiology and chronic health evaluationⅡ,APACHEⅡ)、序贯器官衰竭评价评分(Sequential organ failure assessment,SOFA)以及急性胃肠损伤评分(Acute gastrointestinal injury,AGI)评估患者临床症状改善效果、临床疗效及细菌清除率;观察记录并对比两组在治疗过程中所发生的血小板减少、嗜酸粒细胞增多、贫血等不良反应情况和发生率。结果:两组患者不良反应发生率和细菌清除率,差异无统计学意义(P>0.05);治疗后观察组CRP、PCT、IL-6水平低于对照组,治疗后APACHEⅡ、SOFA、AGI评分均低于对照组,总有效率高于对照组,差异有统计学意义(P<0.05)。结论:替加环素辅助头孢哌酮舒巴坦钠药物对严重腹腔感染患者进行治疗,可有效改善临床症状,降低炎症反应,提升治疗效果,安全性高。Objective:To investigate the effects of tigacycline assisted cefoperazone-sulbactam sodium in the treatment of patients with severe abdominal infection and the changes of inflammatory factor levels and safety.Methods:A total of 80 patients with severe abdominal infection in our department from January 2020 to October 2022 were selected as research objects and divided into control group and observation group according to the lottery method.The control group(n=40)was treated with cefoperazone-sulbactam sodium,and the observation group(n=40)was additionally treated with tigacycline.After 2 weeks of treatment,Interleukin-6(IL-6)level was detected by enzyme-linked immunosorbent assay.Immunochromatography was used to test C-reactive protein(CRP)and Procalcitonin(PCT).The levels of inflammatory factors were compared between the two groups.Acute physiology and chronic health evaluationⅡ(APACHEⅡ),Sequential organ failure assessment(SOFA)and Acute gastrointestinal injury(AGI)to evaluate the improvement effect of clinical symptoms,clinical efficacy and bacterial clearance of patients;The adverse reactions,such as thrombocytopenia,eosinophilia and anemia,were observed and recorded and compared between the two groups during treatment.Results:There was no significant difference in the incidence of adverse reactions and bacterial clearance between 2 groups(P>0.05).After treatment,the levels of CRP,PCT and IL-6 in the observation group were lower than those in the control group,the scores of APACHEⅡ,SOFA and AGI were lower than those in the control group,and the total effective rate was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusions:Tigacycline assisted cefoperazone-sulbactam sodium in the treatment of patients with severe abdominal infection can effectively improve clinical symptoms,reduce inflammatory response,improve therapeutic effect and high safety.

关 键 词：头孢哌酮舒巴坦钠 替加环素 严重腹腔感染 

分 类 号：R459.7[医药卫生—急诊医学]