盐酸非索非那定片联合曲安奈德鼻喷雾剂对变应性鼻炎患者临床疗效及血清cAMP、cGMP水平的影响  

Effects of Fexofenadine hydrochloride tablets combined with Triamcinolone nasal spray on clinical efficacy,serum cAMP and cGMP levels in patients with allergic rhinitis

作　　者：李振刚 强学全 张宝明 Li Zhen-gang;Qiang Xue-quan;Zhang Bao-ming(Department of Otolaryngology,the Third Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China;Department of Otolaryngology,Nanyang Hospital of Traditional Chinese Medicine,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校第三附属医院耳鼻喉科,河南南阳473000 [2]南阳市中医院耳鼻喉头颈外科,河南南阳473000

出　　处：《四川生理科学杂志》2024年第2期314-316,346,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:研究盐酸非索非那定片联合曲安奈德鼻喷雾剂对变应性鼻炎(Allergic rhinitis,AR)患者临床疗效及血清环磷酸腺苷(Cyclic adenosine monophosphate,cAMP)、环磷酸鸟苷(Cyclic guanosine monophosphate,cGMP)水平的影响。方法:采用随机数字表法将我院2021年1月至2022年11月收治的130例AR患者分为对照组、联合组,各65例。对照组采用曲安奈德鼻喷雾剂治疗,联合组采用盐酸非索非那定片联合曲安奈德鼻喷雾剂治疗。治疗4 w评价临床疗效以及临床症状评分(喷嚏、流涕、鼻痒、鼻塞),采用糖精清除试验检测鼻黏膜纤毛传输时间(Mucociliary transport time,MTT)、鼻黏膜纤毛清除率(Meningitis conjugated vaccine,MCV)水平,选用鼻阻力仪检测鼻阻力(Nasal resistance,NR);采用放射免疫分析法检测白细胞介素-5(Interleukin-5,IL-5)、白细胞介素-10(Interleukin-10,IL-10)水平,采用化学发光法检测血清cAMP、cGMP水平;同时观察不良反应发生率。结果:联合组临床总有效率高于对照组(P<0.05);治疗后联合组喷嚏、流涕、鼻痒、鼻塞及临床症状总分、NR、MTT、IL-5、cGMP低于对照组,MCV、IL-10、cAMP高于对照组(P<0.05);两组不良反应总发生率比较,无明显差异(P>0.05)。结论:盐酸非索非那定片联合曲安奈德鼻喷雾剂治疗AR效果显著,能改善鼻腔生理功能,降低机体炎症反应,且不增加不良反应。Objective:To study the clinical efficacy of Fexofenadine hydrochloride tablets combined with triamcinolone nasal spray on allergic rhinitis(AR)and cyclic adenosine monophosphate(cAMP)and cyclic guanosine monophosphate(cGMP)levels in serum.Methods:One hundred and thirty AR patients admitted to our hospital from January 2021 to November 2022 were divided into a control group and a combination group with 65 cases in each group by random number table method.The control group was treated with triamcinolone nasal spray,and the combination group was treated with fexofenadine hydrochloride tablets combined with triamcinolone nasal spray.After 4 weeks of treatment,the clinical efficacy and clinical symptom scores(sneeze,runny nose,nasal itch,and nasal congestion)were compared,and a saccharin clearance test was used to detect the levels of mucociliary transport time(MTT)and nasal ciliary vaccine(MCV).Nasal resistance(NR)was used to detect nasal resistance.The levels of Interleukin-5(IL-5)and Interleukin-10(IL-10)were detected by radioimmunoassay,and the levels of serum cAMP and cGMP were detected by chemiluminescence.Meanwhile,the incidence of adverse reactions was observed.Results:The total clinical effective rate of the combination group was higher than that of the control group(P<0.05).After treatment,sneezing,runny nose,nasal itching,nasal congestion,and total score of clinical symptoms,NR,MTT,IL-5,and cGMP in the combination group were lower than those in the control group,while MCV,IL-10,and cAMP were higher than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Fexofenadine hydrochloride tablets combined with triamcinolone nasal spray have significant effects in the treatment of AR,which can improve the physiological function of the nasal cavity,reduce the inflammatory response of the body,and do not increase adverse reactions.

关 键 词：盐酸非索非那定片 曲安奈德鼻喷雾剂 变应性鼻炎 疗效 环磷酸腺苷 环磷酸鸟苷 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]