非酒精性脂肪性肝病严重程度与颈动脉斑块、内-中膜厚度相关性研究及危险因素分析  

Correlation between the severity of nonalcoholic fatty liver disease and carotid atherosclerosis and intima-media thickness and risk factor analysis

作　　者：马召 任永凤[1] 王洲[1] 李健[1] MA Zhao;REN Yong-feng;WANG Zhou(Department of Ultrasound,Bozhou People′s Hospital,Bozhou Anhui,236800,China)

机构地区：[1]亳州市人民医院B超室,安徽亳州236800

出　　处：《中西医结合肝病杂志》2024年第2期159-162,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：中国红十字基金会医学赋能公益专项基金(No.YXFN-2021LHJY-40)。

摘　　要：目的:探讨非酒精性脂肪性肝病(NAFLD)严重程度与颈动脉斑块、内-中膜厚度(cIMT)之间的关系,并分析其危险因素。方法:收集2021年1至11月行肝脏、颈动脉超声检查并诊断为NAFLD的患者154例,评估患者NAFLD严重程度、颈动脉斑块及血管狭窄程度测量患者cIMT值,计算肝纤维化评分,并进行统计学分析。结果:NAFLD轻度组患者cIMT值、血管狭窄发生率低于中-重度组患者(W=6905.500,P<0.001);有颈动脉斑块组患者cIMT值明显高于无颈动脉斑块组患者(W=3361.500,P<0.001);BMI是NAFLD严重程度的独立危险因素,年龄和NAFLD严重程度是cIMT的独立危险因素,年龄、高血压、肝纤维化评分是颈动脉斑块出现的独立危险因素,差异均有统计学意义(P<0.05)。结论:NAFLD患者cIMT的增加、颈动脉狭窄与NAFLD严重程度有关,其颈动脉斑块发生率与cIMT呈正相关。另外,其肝纤维化评分增加,对颈动脉斑块出现也有提示意义。Objective:To investigate the correlation between the severity of nonalcoholic fatty liver disease(NAFLD)and carotid plaque and carotid intima-media thickness(cIMT),and analyze the risk factors.Methods:A total of 154 patients who underwent liver and carotid ultrasound examination and were diagnosed with NAFLD from January to November 2021 were collected.The severity of NAFLD,carotid plaque and vascular stenosis were evaluated to measure the cIMT value of the patients,and the liver fibrosis score was calculated,and the statistical analysis was performed.Results:The cIMT and incidence of stenosis were lower in the mild NAFLD group than in the moderate-severe group,and the differences were statistically significant(W=6905.500,P<0.001).cIMT values were significantly higher in the group with carotid atherosclerotic plaque than in the group without carotid atherosclerotic plaque,and the differences were statistically significant(W=3361.500,P<0.001).BMI was an independent risk factor for NAFLD severity and cIMT,age and NAFLD severity were an independent risk factor for cIMT.Age,hypertension,and liver fibrosis score were independent risk factors for carotid atherosclerotic plaque,with statistically significant differences(P<0.05).Conclusion:The increase of cIMT and carotid stenosis are related to the severity of NAFLD,and the incidence of carotid plaque is positively correlated with cIMT.In addition,increasing liver fibrosis score was indicative of the presence of carotid atherosclerotic plaque.

关 键 词：非酒精性脂肪性肝病 颈动脉斑块 内-中膜厚度 

分 类 号：R445[医药卫生—影像医学与核医学]