Dietary supplementation of zinc oxide modulates intestinal functionality during the post-weaning period in clinically healthy piglets  

作　　者：Dirkjan Schokker Soumya K.Kar Els Willems Alex Bossers Ruud A.Dekker Alfons J.M.Jansman 

机构地区：[1]Wageningen Bioveterinary Research,Lelystad,The Netherlands [2]Wageningen Livestock Research,Wageningen University&Research,Wageningen,The Netherlands [3]Royal Agrifirm Group,Apeldoorn,The Netherlands [4]Institute for Risk Assessment Sciences,Utrecht University,Utrecht,The Netherlands

出　　处：《Journal of Animal Science and Biotechnology》2024年第1期313-328,共16页畜牧与生物技术杂志（英文版）

基　　金：partially funded by the Ministry of Agriculture;Nature and Food Quality(project number BO-55-001-015);partly by“Vereniging Diervoederonderzoek Nederland”。

摘　　要：Background To improve our understanding of host and intestinal microbiome interaction,this research investigated the effects of a high-level zinc oxide in the diet as model intervention on the intestinal microbiome and small intestinal functionality in clinically healthy post-weaning piglets.In study 1,piglets received either a high concentration of zinc(Zn)as zinc oxide(Zn O,Zn,2,690 mg/kg)or a low Zn concentration(100 mg/kg)in the diet during the post weaning period(d 14–23).The effects on the piglet's small intestinal microbiome and functionality of intestinal tissue were investigated.In study 2,the impact of timing of the dietary zinc intervention was investigated,i.e.,between d 0–14 and/or d 14–23 post weaning,and the consecutive effects on the piglet's intestinal functionality,here referring to microbiota composition and diversity and gene expression profiles.Results Differences in the small intestinal functionality were observed during the post weaning period between piglets receiving a diet with a low or high concentration Zn O content.A shift in the microbiota composition in the small intestine was observed that could be characterized as a non-pathological change,where mainly the commensals inter-changed.In the immediate post weaning period,i.e.,d 0–14,the highest number of differentially expressed genes(DEGs)in intestinal tissue were observed between animals receiving a diet with a low or high concentration Zn O content,i.e.,23 DEGs in jejunal tissue and 11 DEGs in ileal tissue.These genes are involved in biological processes related to immunity and inflammatory responses.For example,genes CD59 and REG3G were downregulated in the animals receiving a diet with a high concentration Zn O content compared to low Zn O content in both jejunum and ileum tissue.In the second study,a similar result was obtained regarding the expression of genes in intestinal tissue related to immune pathways when comparing piglets receiving a diet with a high concentration Zn O content compared to low Zn O content.Conclu

关 键 词：Immune system Intestinal functionality MICROBIOTA PIGLETS Zinc oxide 

分 类 号：S828.5[农业科学—畜牧学]