利用生物打印技术“自下而上”地设计生物组织  

Designing biological tissues from the bottom-up using bioprinting technology

作　　者：沈利红 詹怡辰 姜文彬 汪振星 刘志荣 SHEN Lihong;ZHAN Yichen;JIANG Wenbin;WANG Zhenxing;LIU Zhirong(Department of Plastic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Wuhan Clinical Research Center for Superficial Organ Reconstruction,Wuhan 430022,China.)

机构地区：[1]华中科技大学同济医学院附属协和医院整形外科,湖北省武汉市430022 [2]武汉市浅表器官再造临床研究中心,湖北省武汉市430022

出　　处：《组织工程与重建外科》2024年第1期121-128,141,共9页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：国家优秀青年科学基金项目(82322046);国家自然科学基金项目(82072198,82002067)。

摘　　要：随着人们对组织和器官需求的不断增长,组织工程领域取得了长足的发展。然而,再造具有功能的组织和器官仍然是一个巨大挑战。近些年,为了构建具有生理功能的组织,不少研究提出了“自下而上”的组织工程策略。该策略主要包括两个关键步骤:模块化组织的构建和组织模块的组装。生物打印技术因其高度自动化、在高精度组织工程方面的卓越能力以及构建多成分组织的潜力,在“自下而上”的组织构建研究中得到广泛应用。在本综述中,我们分别总结了应用于模块化组织制造和组装的技术,特别阐述了“自下而上”生物打印的机制和应用,最后总结了“自下而上”组织工程未来趋势,希望为该领域的研究人员提供有用的参考和灵感。The field of tissue engineering has grown considerably over the decades as the demand for tissues and organs continues to grow.However,recreating functional tissues and organs is still a great challenge.In recent years,a number of researchers have proposed a“bottom-up”tissue engineering strategy to construct physiologically functional tissues.This strategy consists of two key steps:First,the construction of modular tissues,followed by the assembly of tissue modules.Bioprinting technology has been widely used in“bottom-up”tissue construction studies due to its high degree of automation,superior ability in high-precision tissue engineering,and potential for building multi-component tissues.In this review,the technologies applied to modular tissue fabrication and assembly were summarized,with a special focus on the mechanisms and applications of“bottom-up”bioprinting.Finally,the future trends of“bottom-up”tissue engineering were summarized,hoping to provide useful references and inspirations for researchers in this field.

关 键 词：组织工程 生物制造 生物打印 模块化组织 组装 

分 类 号：R318.1[医药卫生—生物医学工程]