Protecting-group-free ortho-C–H borylation of anilines enabled by mesoionic carbene-Ir complex  

作　　者：Zengyu Zhang Shiqing Huang Wei Liu Liang-Liang Zhao Chubin Hu Xiaoyu Yan 

机构地区：[1]Key Laboratory of Advanced Light Conversion Materials and Biophotonics,Department of Chemistry,Renmin University of China,Beijing 100872,China

出　　处：《Green Synthesis and Catalysis》2023年第4期300-305,共6页绿色合成与催化（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.22171284 and 21602249);the Fundamental Research Funds for the Central Universities,the Research Funds of Renmin University of China(No.20XNLG20);the Public Computing Cloud Platform,Renmin University of China.

摘　　要：We describe an iridium-catalyzed ortho-selective C–H borylation of unprotected anilines.The employing strongσ-donating cyclometalated mesoionic carbene as C^C bidentate ligand is crucial for the high ortho-selectivity.Computational studies support outer-sphere X–H⋅⋅⋅O_(boryl) hydrogen bond interactions,which are strengthened by bidentate C^C ligand introduction.The method shows broad substrate scope and high functional group tolerance.

关 键 词：Protecting-group-free C-H borylation Hydrogen bonding Regioselectivity Mesoionic carbene 

分 类 号：O62[理学—有机化学]