Electrochemical synthesis of 3-halogenated spiro [4,5]trienones based on dearomative spirocyclization strategy  

作　　者：Zhiwei Chen Wei Tang Shuhang Yang Luyao Yang 

机构地区：[1]College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China

出　　处：《Green Synthesis and Catalysis》2023年第4期306-310,共5页绿色合成与催化（英文）

基　　金：We gratefully acknowledge the Provincial Planning Project of the Zhejiang Provincial Science and Technology Department(No.LGF19B060005)for financial support.

摘　　要：A novel and green route have been developed for the electrochemical synthesis of 3-halogenated spiro[4.5]trienones based on dearomative spirocyclization of alkynes with NaX(Br,I)as the halogen source.This transformation was performed in an undivided cell under mild conditions.A wide range of substituted 3-halogenated spiro[4.5]trienones products was prepared in moderate-to-good yields,showing a broad scope and functional group tolerance.In addition,this approach was further extended to access fused tricyclic 6,7-dihydro-3H-pyrrolo[2,1-j]quinoline-3,9(5H)-diones.

关 键 词：Electrochemistry Spiro-cyclization METAL-FREE Tricyclic frameworks Spiro[4 5]trienones 

分 类 号：O646[理学—物理化学]