Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides  

作　　者：Wei-Yi Pu Xin-Yi Chen Lin Dong 

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Green Synthesis and Catalysis》2023年第4期338-341,共4页绿色合成与催化（英文）

基　　金：We are grateful for the financial support from 111 Project(No.B18035)and“the Fundamental Research Funds for the Central Universities”.

摘　　要：Transition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds.However,modification of 2-oxyl benzimidazole skeleton using maleimide compounds via C–H activation has remained unprecedented.Herein,we developed a rhodium(III)-catalyzed[5+1]cascade spiroannulation to construct diversified novel benzimidazole-incorporated spirosuccinimide derivatives from 2-oxyl benzimidazoles and maleimides.

关 键 词：Rh(III)-catalysis 2-Oxyl benzimidazole MALEIMIDES SPIROCYCLIZATION 

分 类 号：O62[理学—有机化学]