Simple nucleophile/H_(2)O promoted defluorinative ring-opening of gem-difluorocyclopropenes  

作　　者：Yimiao He Jingwen Yuan Wen-Xin Lv Peng Liu Fan Teng Qijin Mo Zihua Wu Chusheng Huang Qianwen Liu Honggen Wang 

机构地区：[1]Guangxi Key Laboratory of Natural Polymer Chemistry and Physics,College of Chemistry and Materials,Nanning Normal University,Nanning,530001,China [2]School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,510006,China [3]School of Chemistry,Chemical Engineering,and Biotechnology,Nanyang Technological University,117543,Singapore [4]Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou,510530,China [5]Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle,Nanchang Hangkong University,Nanchang,330063,China

出　　处：《Green Synthesis and Catalysis》2024年第1期14-19,共6页绿色合成与催化（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China(Nos.21861007 and 21702034);Natural Science Foundation of Guangxi Province(Nos.2021GXNSFAA075024 and 2022GXNSFAA035468);the Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010624);Natural Science Foundation of Jiangxi Province of China(No.20212BAB213024);“BAGUI Scholar”Program of Guangxi Province of China.

摘　　要：A novel defluorinative ring-opening of gem-difluorocyclopropenes is presented,providing a concise and efficient method for accessing 2-fluoropropenals and 2-fluorobuta-1,3-dienes in moderate to good yields with excellent regio-and stereoselectivities.The reaction is performed under mild conditions with no need of using an excess amount of nucleophilic reagents.Water plays a crucial role in this transformation.

关 键 词：gem-difluorocyclopropene Ring-opening defluorination 2-Fluoropropenal 2-Fluorobuta-1 3-diene Water 

分 类 号：O62[理学—有机化学]