Visible-light-induced decarboxylative alkynylation of carboxylic acids in batch and continuous flow  

作　　者：Longzhou Qin Xinpeng Zhang Hao Sun Xiu Duan Jie Liu Mengyu Wu Xin Yuan Jiangkai Qiu Kai Guo 

机构地区：[1]College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211816,China [2]State Key Laboratory of Materials-Oriented Chemical Engineering,Nanjing Tech University,Nanjing 211816,China

出　　处：《Green Synthesis and Catalysis》2024年第1期20-24,共5页绿色合成与催化（英文）

基　　金：We are grateful for financial support from the National Natural Science Foundation of China(Nos.21702103 and 21522604);the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(No.XTD2203);the Natural Science Research Projects of Jiangsu Higher Education(No.19KJB150027).

摘　　要：A green efficient photoredox-catalyzed decarboxylative alkynylation of carboxylic acids with alkynyl bromides has been developed.This broadly applicable protocol is presented whereinα-amino,aliphatic andα-oxy acids are converted into useful alkynylation products.The commercially-available organic photocatalyst 4CzIPN is used as the photocatalyst,organic base DBU is utilized as the base,and DMSO serves as solvent.This strategy features mild conditions,is metal-free,and is environmentally friendly.The batch and continuous-flow protocols described were applied to obtain a broader substrate scope of functionalization(more than 50 examples).Furthermore,we demonstrate that the use of microflow technology enhanced and intensified the reaction process,achieving significantly reduced reaction times(i.e.,10 min of residence time).

关 键 词：Visible-light-induced Decarboxylative alkynylation Continuous flow METAL-FREE 

分 类 号：O62[理学—有机化学]