Catalyst-free and atom-economical [4+3] cycloaddition of azadienes with cyclic azomethine imines for facile synthesis of 1,2,4-triazepines  

作　　者：Lesong Li Tao Liu Weiwu Ren Yang Wang 

机构地区：[1]Molecular Synthesis Center&Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China [2]Laboratory for Marine Drugs and Bioproducts,Qingdao National Laboratory for Marine Science and Technology(QNLM),Qingdao 266237,China

出　　处：《Green Synthesis and Catalysis》2024年第1期57-61,共5页绿色合成与催化（英文）

基　　金：We thank the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(QNLM)(No.2022QNLM030003-2);the Fundamental Research Funds for the Central Universities,Ocean University of China,Qingdao National Laboratory for Marine Science and Technology(Nos.LMDBCXRC201902 and LMDBCXRC201903);Taishan Scholar Program of Shandong Province(Nos.tsqn201909056 and tsqn202103152);National Natural Science Foundation of China(No.22171251);Natural Science Foundation of Shandong Province(No.ZR2021QB033)for financial support.

摘　　要：A catalyst-free and atom-economical[4+3]cycloaddition of azadienes with C,N-cyclic azomethine imines has been developed,providing an efficient and environmentally benign access to 1,2,4-triazepines with high diastereoselectivities and yields.This reaction can be performed in 2-methyltetrahydrofuran under mild conditions smoothly.

关 键 词：CATALYST-FREE Atom-economical[4+3] Cycloaddition C N-cyclic Azomethine imine Azadiene 1 2 4-triazepine 

分 类 号：O62[理学—有机化学]